Anti-inflammatory and Antitumor-Promoting Effects of the Triterpene Acids from the Leaves of Eriobotrya japonica(Pharmacognosy)

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概要

• 論文の詳細を見る

• Sixteen triterpene acids, viz., five of the oleanane-type (1-5), nine of the ursane-type (6-14), and two of the lupane-type (15, 16), were isolated and identified from the ethyl acetate-soluble fraction of the methanol extract of the leaves of loquat, Eriobotrya japonica LINDL. (Rosaceae). Twelve of these compounds, 1-4, 6, 8-13, and 15, were evaluated for their inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation (1μg/ear) in mice. All the compounds tested showed a marked anti-inflammatory effect, with a 50% inhibitory dose (ID_<50>) of 0.03-0.43mg per ear. In addition, an evaluation against the Epstein-Barr virus early antigen (EBV-EA) activation induced by TPA for all of the compounds, 12 and 13 showed potent inhibitory effects on EBV-EA induction. Furthermore, euscaphic acid (12) exhibited marked antitumor-promoting activity in an in vivo two-stage carcinogenesis test of mouse tumor by using 7, 12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter.

• 公益社団法人日本薬学会の論文
• 2005-10-01

著者

• Suzuki Takashi

  College of Pharmacy, Nihon University

• Akihisa Toshihiro

  College of Science and Technology, Nihon University

• TOKUDA Harukuni

  Department of Molecular Biochemistry, Kyoto Prefectural University of Medicine

• Suzuki T

  Department Of Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences:core Research Fo

• NISHINO Hoyoku

  Department of Biochemistry, Kyoto Prefectural University of Medicine

• Banno Norihiro

  Ichimaru Pharcos Company Ltd.

• Kimura Y

  Coll. Of Pharmacy Nihon Univ.

• Kimura Yumiko

  College Of Pharmacy Nihon University

• AKAZAWA Hiroyuki

  College of Science and Technology, Nihon University

• TAGUCHI Yosuke

  College of Science and Technology, Nihon University

• YASUKAWA Ken

  College of Pharmacy, Nihon University

• Nishino H

  Toho University School Of Pharmaceutical Sciences

• Nishino H

  Department Of Biochemistry Kyoto Prefectural University Of Medicine

• Nishino H

  Department Of Biochemistry And Molecular Biology Kyoto Prefectural University Of Medicine

• Nishino Hoyoku

  Department Of Biochemistry And Molecular Biology Graduate School Of Medical Science Kyoto Prefectura

• Suzuki T

  Department Of Pharmaceutics College Of Pharmacy Nihon University

• Suzuki Takashi

  School Of Pharmacy Nihon Univ.

• TOKUDA Harukuni

  Kyoto Prefectural University of Medicine

• UKIYA Motohiko

  College of Science and Technology, Nihon University

• Banno Norihiro

  Ichimaru Pharcos Co. Ltd.

• Yasukawa Ken

  Coll. Of Pharmacy Nihon Univ.

• Yasukawa Ken

  College Of Pharmacy Nihon University

• Akihisa T

  College Of Pharmacy Nihon University

• Akihisa Toshihiro

  日本大学 理工学部

• Akihisa Toshihiro

  College Of Science And Technology Nihon University

• Tokuda Harukuni

  Dep. Of Complementary And Alternative Medicine Clinical R&d Graduate School Of Medical Sci. Kana

• Tokuda Harukuni

  Department Of Biochemistry And Molecular Biology Kyoto Prefectural University Of Medicine

• Taguchi Yosuke

  College Of Science And Technology Nihon University

• Ukiya Motohiko

  College Of Science And Technology Nihon University

• Suganuma Taiyo

  (pressent Address)department Of Pharmacology Tokyo Women's Medical University

• Suzuki Takashi

  Department Of Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences:core Research Fo

• Takase S

  College Of Science And Technology (funabashi Campus) Nihon University

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