Xanthoangelol, a Major Chalcone Constituent of Angelica keiskei, Induces Apoptosis in Neuroblastoma and Leukemia Cells(Pharmacology)

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概要

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• Xanthoangelol, a major chalcone constituent of the stem exudates of Angelica keiskei, was evaluated for cell toxicity and apoptosis-inducing activity in human neuroblastoma (IMR-32) and leukemia (Jurkat) cells. Xanthoangelol concentration-dependently reduced the survival rates of both cell lines as revealed by the trypan blue exclusion test. Early apoptosis induced by 4h incubation with xanthoangelol was detected using flow cytometry after double-staining with annexin V and propidium iodide (PI). Western blot analysis showed that xanthoangelol markedly reduced the level of precursor caspase-3 and increased the level of cleaved caspase-3, but Bax and Bcl-2 proteins were not affected. These results suggest that xanthoangelol induces apoptotic cell death by activatation of caspase-3 in neuroblastoma and leukemia cells through a mechanism that does not involve Bax/Bcl-2 signal transduction. Therefore, xanthoangelol may be applicable as an effective drug for treatment of neuroblastoma and leukemia.

• 社団法人日本薬学会の論文
• 2005-08-01

著者

• HASEGAWA Daisuke

  Department of Pediatrics, St. Luke's International Hospital

• Tabata Keiichi

  日本大学 薬学部臨床医学ユニット

• Motani Kou

  Research Unit Of Clinical Medicine College Of Pharmacy Nihon University

• Motani Kou

  日本大学 薬学部臨床医学ユニット

• Suzuki T

  Department Of Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences:core Research Fo

• Kimura Y

  Coll. Of Pharmacy Nihon Univ.

• AKIHISA Toshihiro

  Department of Materials and Applied Chemistry, College of Science and Technology, Nihon University

• TABATA Keiichi

  Clinical Pharmacy, College of Pharmacy, Nihon University

• ASAMI Satoru

  Clinical Pharmacy, College of Pharmacy, Nihon University

• SuzuKi Takashi

  Clinical Pharmacy, College of Pharmacy, Nihon University

• MOTANI Kou

  Clinical Pharmacy, College of Pharmacy, Nihon University

• TAKAYANAGI Noriya

  Clinical Pharmacy, College of Pharmacy, Nihon University

• NISHIMURA Reiko

  Clinical Pharmacy, College of Pharmacy, Nihon University

• KIMURA Yumiko

  Chemical Analysis Center, College of Pharmacy, Nihon University

• UKIYA Motohiko

  Department of Materials and Applied Chemistry, College of Science and Technology, Nihon University

• Suzuki T

  Department Of Pharmaceutics College Of Pharmacy Nihon University

• Suzuki Takashi

  School Of Pharmacy Nihon Univ.

• ASAMI Satoru

  Research Unit of Clinical Medicine, College of Pharmacy, Nihon University

• UKIYA Motohiko

  College of Science and Technology, Nihon University

• Nishimura Reiko

  Research Unit Of Clinical Medicine College Of Pharmacy Nihon University

• Hasegawa Daisuke

  Department Of Materials And Applied Chemistry College Of Science And Technology Nihon University

• Yasukawa Ken

  Coll. Of Pharmacy Nihon Univ.

• Akihisa T

  College Of Pharmacy Nihon University

• Akihisa Toshihiro

  日本大学 理工学部

• Akihisa Toshihiro

  Department Of Materials And Applied Chemistry Collegeof Science And Technology Nihon University

• Akihisa Toshihiro

  College Of Science And Technology Nihon University

• Asami Satoru

  Research Unit Of Clinical Medicine College Of Pharmacy Nihon University

• Ukiya Motohiko

  College Of Science And Technology Nihon University

• Suzuki Takashi

  Department Of Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences:core Research Fo

• Hasegawa Daisuke

  Department Of Aerospace Engineering Tokyo Metropolitan Institute Of Technology

• Takayanagi Noriya

  Clinical Pharmacy College Of Pharmacy Nihon University

• Tabata Keiichi

  School Of Pharmacy Nihon University

• Takase S

  College Of Science And Technology (funabashi Campus) Nihon University

• Suzuki Takashi

  Clinical And Biotechnology Business Unit Shimadzu Corporation

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