Evaluation of the Degree of Mixing of Combinations of Dry Syrup, Powder, and Fine Granule Products in Consideration of Particle Size Distribution Using Near Infrared Spectrometry
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概要
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We used near infrared (NIR) spectroscopy to evaluate the degree of mixing of blended dry syrup (DS) products whose particle sizes are not specified in the Revised 16th Edition of the Japanese Pharmacopoeia, and also evaluated the degree of mixing when powder products or fine granule products were added to DS products. The data obtained were used to investigate the relationship between the particle size distributions of the products studied and the degree of mixing. We found that the particle size distribution characteristics of the 15 DS products studied can be broadly classified into 5 types. Combinations of frequently prescribed products were selected to represent 4 of the 5 particle size distribution types and were blended with a mortar and pestle. The coefficient of variation (CV) decreased as the percent mass of Asverin® Dry Syrup 2% (Asverin-DS) increased in blends of Periactin® Powder 1% (Periactin) and Asverin-DS, indicating an improved degree of mixing (uniformity). In contrast, in blends of Periactin and Mucodyne® DS 33.3%, mixing a combination at a 1 : 1 mass ratio 40 times resulted in a CV of 20%. Other mixing frequencies and mass ratios resulted in a CV by 50% to 70%, indicating a very poor degree of mixing (poor uniformity). These results suggest that when combining different DSs, or a DS with a powder or fine granule product, the blending obtained with a mortar and pestle improves as the particle size distributions of the components approach each other and as the ranges of the distributions narrow.
- 公益社団法人 日本薬学会の論文
著者
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Matsumoto Mika
Department of Internal Medicine, Cardiovascular Division Hyogo College of Medicine
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Suzuki T
Department Of Pharmaceutics College Of Pharmacy Nihon University
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Ohtani Michiteru
Department Of Hospital Pharmacy Tokyo Postal Service Agency Hospital
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Yamamoto Yoshihisa
Faculty Of Engineering Kyushu University
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Suzuki Toyofumi
Laboratory of Pharmaceutics, Nihon University School of Pharmacy
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Hayano Shuichi
Bruker Optics K.K.
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Fukami Toshiro
Laboratory of Pharmaceutics, Nihon University School of Pharmacy
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Tomono Kazuo
Laboratory of Pharmaceutics, Nihon University School of Pharmacy
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Matsumoto Mika
Department of Pharmacy, Tokyo Posts and Telecommunications Hospital
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