Effect of Permeation Enhancers on the in Vitro Percutaneous Absorption of Pentazocine(Biopharmacy)
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概要
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The effect of permeation enhancers on the percutaneous absorption of pentazocine (PTZ) was investigated in excised hairless mice using Franz diffusion cells in vitro. The enhancing effect on the percutaneous absorption of PTZ from the isopropyl myristate (IPM) solution system was improved with glyceryl monocaprylate (GEFA-C_8), which is a kind of glycerol ester of fatty acid (GEFA). The flux of PTZ through the skin was ca. 4 times higher compared with IPM alone, while a less enhancing effect of glyceryl dicaprylate (GEFA-DiC_8) and glyceryl tricaprylate (GEFA-TriC_8) on the skin permeation of PTZ was found. Moreover, maximum enhancement of PTZ flux was observed with glyceryl monocaproate (GEFA-C_6) among various alkyl chains (C_2-C_<18>) of monoglycerides. These results indicated that the IPM solution system combination with GEFA may be used to develop a transdermal formulation with improved skin permeation of PTZ.
- 2007-07-01
著者
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Suzuki T
Department Of Pharmaceutics College Of Pharmacy Nihon University
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Fukami Toshiro
Department Of Pharmaceutics College Of Pharmacy Nihon University
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Tomono K
Res. Unit Of Pharmaceutics Coll. Of Pharmacy Nihon Univ.
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Tomono K
Nihon Univ. Chiba Jpn
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Tomono Kazuo
Department Of Pharmaceutics College Of Pharmacy Nihon University
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Furuishi Takayuki
Research Unit of Pharmaceutics, College of Pharmacy, Nihon University
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Fukami Toshiro
Research Unit of Pharmaceutics, College of Pharmacy, Nihon University
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Suzuki Toyofumi
Research Unit of Pharmaceutics, College of Pharmacy, Nihon University
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Tomono Kazuo
Research Unit of Pharmaceutics, College of Pharmacy, Nihon University
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ODA Sachiko
Research Unit of Pharmaceutics, College of Pharmacy, Nihon University
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SAITO Hiroaki
Research Unit of Organic Chemistry, College of Pharmacy, Nihon University
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Oda Sachiko
Research Unit Of Pharmaceutics College Of Pharmacy Nihon University
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Suganuma Taiyo
(pressent Address)department Of Pharmacology Tokyo Women's Medical University
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Suzuki Takashi
Department Of Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences:core Research Fo
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Tomono Kazuo
Research Unit Of Pharmaceutics College Of Pharmacy Nihon University
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Suzuki Toyofumi
Research Unit Of Pharmaceutics College Of Pharmacy Nihon University
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Furuishi Takayuki
Research Unit Of Pharmaceutics College Of Pharmacy Nihon University
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Saito Hiroaki
Research Unit Of Organic Chemistry College Of Pharmacy Nihon University
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