Useful Markers for Detecting Minimal Residual Disease in Cases of Neuroblastoma(Molecular and Cell Biology)
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概要
- 論文の詳細を見る
Neuroblastoma (NB), which is a malignant tumor of young children derived from neural crest cells that occurs in children, exhibits a wide range of clinical behaviors, from spontaneous regression to rapid progression. Advanced NB patients have a poor prognosis, and recently, autologous bone marrow transplantation (BMT) and autologous peripheral blood stem cell transplantation (PBSCT) have been attempted to improve the prognosis of these patients. In this study, we attempted to detect the expression of tyrosine hydroxylase (TH), neuroendocrine protein gene product (PGP) 9.5, ELAVL-4 and GD2 synthetase (GALGT), all of which are highly expressed in NBs, by the reverse transcription-polymerase chain reaction (RT-PCR) technique in order to detect minimal residual disease (MRD) in the bone marrow (BM) and peripheral blood (PB). Analysis of various tumor cell lines (Ewing's sarcoma, hepatoma, leukemias, and breast cancer cell lines in addition to NBs), and human normal samples (BM and PB cells) revealed that TH was the most specific marker for the detection of NB. On the other hand, PGP9.5 was the most sensitive marker, and was detected even when there was only one positive cell per 10^7 negative cells. We concluded that TH is a better marker before the diagnosis of NB while PGP9.5 is a better marker to detect MRD after the diagnosis. Here, we describe our results on useful markers to detect MRD in patients with NB.
- 公益社団法人日本薬学会の論文
- 2008-06-01
著者
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Nemoto Norimichi
Department of Pathology, Nihon University School of Medicine
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MUGISHIMA Hideo
Department of Division of Cell Regeneration and Transplantation, Nihon University School of Medicine
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Mugishima H
Department Of Pediatrics Division Of Cell Regeneration And Transplantation Advanced Medical Research
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Mugishima Hideo
日本大学 医学部小児科学
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Mugishima H
日本大学 医学部小児科学
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CHIN MOTOAKI
Department of Pediatrics, Advanced Medical Research Center, Nihon University School of Medicine
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Suzuki T
Department Of Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences:core Research Fo
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SUZUKI Takashi
Research Institute for Scientific Measurements,Tohoku University
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Nemoto Norimichi
Division Of Pathology Department Of Pathology And Microbiology Nihon University School Of Medicine
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Nemoto Norimichi
Department Of Iind Pathology Nihon University School Of Medicine
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Yoshida Y
Department Of Orthopedic Surgery Nihon University
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Suzuki T
Department Of Pharmaceutics College Of Pharmacy Nihon University
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Suzuki Takashi
School Of Pharmacy Nihon Univ.
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Hinotsu Shiro
Japanese Wilms Tumor Study (JWiTS) Group
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Chin Motoaki
Japanese Wilms Tumor Study (JWiTS) Group
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Mugishima Hideo
Japanese Wilms Tumor Study (JWiTS) Group
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SHICHINO Hiroyuki
Department of Pediatrics, School of Medicine
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OOTSUKA Susumu
Research Unit of Clinical Medicine, College of Pharmacy, Nihon University
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ASAMI Satoru
Research Unit of Clinical Medicine, College of Pharmacy, Nihon University
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SASAKI Takae
Research Unit of Clinical Medicine, College of Pharmacy, Nihon University
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YOSHIDA Yoshikazu
Department of Hospital Pharmacy, Nihon University
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Asami Satoru
Research Unit Of Clinical Medicine College Of Pharmacy Nihon University
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Osaka S
Department Of Orthopedic Surgery Nihon University Nerima Hikarigaoka Hospital
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Ootsuka Susumu
Research Unit Of Clinical Medicine College Of Pharmacy Nihon University:department Of Hospital Pharm
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Suganuma Taiyo
(pressent Address)department Of Pharmacology Tokyo Women's Medical University
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Suzuki Takashi
Department Of Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences:core Research Fo
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Nemoto Norimichi
Nihon Univ. School Of Medicine Tokyo Jpn
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Shichino Hiroyuki
Department Of Pediatrics Division Of Cell Regeneration And Transplantation Advanced Medical Research
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Chin Motoaki
Department Of Pediatrics Division Of Cell Regeneration And Transplantation Advanced Medical Research
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Yoshida Y
Department Of Orthopedic Surgery Nihon University School Of Medicine
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Chin Motoaki
Department Of Pediatrics And Child Health Nihon University School Of Medicine
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Takase S
College Of Science And Technology (funabashi Campus) Nihon University
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Yoshida Yoshikazu
Department Of Electrical Engineering Faculty Of Engineering Tohoku University
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Hinotsu Shiro
Department Of Pharmacoepidemiology Kyoto University Graduate School Of Medicine And Public Health
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Suzuki Takashi
Research Faculty Of Agriculture Hokkaido University
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