Change of β-Endorphin Concentration in Rat Brain after Administration of Indomethacin or Carrageenin
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概要
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This study aimed to investigate the behavior of an endogenous β-endorphin (β-EP) in the brain after subcutaneous (s.c.) injection of carrageenin or intravenous (i.v.) injection of indomethacin (IDM). The carrageenin was injected into rat hind paw subcutaneously in order to evoke only a local nociceptive stimulus. The β-EP concentration in the brain region was determined by radioimmunoassay at designated sampling times after the injection. It was observed that the β-EP concentration in the midbrain declined from 2.8±0.3 at 1 h to 1.3±0.02 ng/mg protein at 9h. After the s.c. injecction of carrageenin, the β-EP concentrations in the midbrain were found to be closely related to the nociceptive sensitivity which was determined by the Randall-Selitto test. On the other hand, a significant elevation of the β-EP concentration was observed in the hypothalamus from 3 h until 5 h compared with that of control. IDM was injected into rats at doses of 2.9,5.8 and 8.6 mg/kg via the femoral vein. After i.v. administration of IDM, the β-EP increased in the hypothalamus, medulla oblongata, and midbrain, depending on the doses used. The value of hypothalamic β-EP concentration was two times higher than that of carrageenin. We found that nociceptive stimuli and IDM brought a change in the β-EP concentration in the brain of rats.
- 公益社団法人日本薬学会の論文
- 1998-07-15
著者
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Suzuki T
Department Of Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences:core Research Fo
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Hanano Manabu
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Tokyo
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SUZUKI Toyofumi
Department of Pharmaceutics, College of Pharmacy, Nihon University
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Hanano Manabu
Faculty Of Pharmaceutical Sciences University Of Tokyo
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Hanano M
Department Of Pharmaceutics College Of Pharmacy Nihon University
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Hanano M
Department Of Pharmaceutical Science College Of Pharmacy Nihon University
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Hanano M
Faculty Of Pharmaceutical Sciences University Of Tokyo
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Hanano Manabu
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University:department
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SUGANUMA Taiyo
Department of Medical Eudcation, Tokyo Women's Medical University School of Medicine
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Suganuma Taiyo
(pressent Address)department Of Pharmacology Tokyo Women's Medical University
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Suganuma Taiyo
Department Of Medical Eudcation Tokyo Women's Medical University School Of Medicine
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OSHIMI Masakazu
Department of Pharmaceutical Science, College of Pharmacy, Nihon University
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Oshimi Masakazu
Department Of Pharmaceutical Science College Of Pharmacy Nihon University
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Suzuki Takashi
Department Of Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences:core Research Fo
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Suganuma Taiyo
Department Of Medical Education Tokyo Women's Medical University
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