INTERINDIVIDUAL DIFFERENCES IN THE PLASMA PROTEIN BINDING OF 1-ANILINO-8-NAPHTHALENESULFONATE AND PHENYLBUTAZONE IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
There were pronounced interindividual differences in the plasma protein binding of 1-anilino-8-naphthalenesulfonate (ANS) and phenylbutazone in rats. A highly statistically significant positive correlation was observed between the free fraction of ANS and phenylbutazone (r=0.896,p<0.001), and the possibility of the application of ANS to a clinical test was discussed. Kinetic analysis of ANS binding to individual rat plasma revealed the presence of endogenous competitive inhibitors. Free fatty acids (FFA) were suggested for one of the endogenous inhibitors, since the free fraction of ANS and the FFA concentration were related with a correlation coefficient of 0.609 (p<0.001).
- 公益社団法人日本薬学会の論文
著者
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Hanano M
Department Of Pharmaceutics College Of Pharmacy Nihon University
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Hanano Manabu
Faculty Of Pharmaceutical Science University Of Tokyo
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Sugiyama Yuichi
Faculty Of Pharmaceutical Sciences University Of Tokyo
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Sugiyama Yuichi
Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Sato Jun
Faculty Of Pharmaceutical Sciences University Of Tokyo
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Sato Jun
Faculty Of Engineering Toyo University
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