INTESTINAL ABSORPTION OF dl-α-TOCOPHEROL FROM BILE SALTS AND POLYSORBATE 80 MICELLAR SOLUTIONS IN RAT
スポンサーリンク
概要
- 論文の詳細を見る
The intestinal absorption of dl-α-tocopherol (VE) from various micellar solutions was studied by the in situ recirculating perfusion in rat small intestine. The perfused micellar solutions of VE were formed by sodium taurocholate (STC), sodium taurodeoxycholate (STDC) or polysorbate 80 (PS-80). The absorption ratio of VE was STC>STDC>PS-80 micellar solutions. The addition of egg lecithin (PC) to all micellar solutions caused the decrease of the absorption. The absorption ratio did not necessarily have a simple correlation with the VE solubilization in these micellar solutions. And it was also found that the absorption ratio correlated with the micellar size and with net water flux in the intestinal lumen.
- 公益社団法人日本薬学会の論文
著者
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HANANO Manabu
Faculty of Pharmaceutical Sciences, University of Tokyo
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Hanano Manabu
Faculty Of Pharmaceutical Science University Of Tokyo
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Awazu Shoji
Department Of Biopharmaceutics Tokyo College Of Pharmacy:department Of Pharmaceutics Research Center
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Awazu Shoji
Faculty Of Pharmaceutical Science University Of Tokyo:(present Address)tokyo College Of Pharmacy
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Awazu Shoji
Department Of Biopharmaceutics Tokyo College Of Pharmacy
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Awazu S
Department Of Biopharmaceutics Tokyo College Of Pharmacy:department Of Pharmaceutics Research Center
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Hayashi Masahiro
Faculty Of Agriculture Miyazaki University
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Imai Jun
Faculty Of Pharmaceutical Sciences University Of Tokyo:(present Address)central Research Laboratorie
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