IMPROVEMENT OF BIOAVAILABILITY OF POORLY ABSORBED DRUGS.I.EFFECT OF MEDIUM CHAIN GLYCERIDE BASE ON THE RECTAL ABSORPTION OF CEFMETAZOLE SODIUM IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
The effect of medium chain glyceride on the rectal absorption of cefmetazole sodium is investigated using an in situ experiment in rats. Each glyceride component of medium chain glyceride was separated using a high-performance liquid chromatographic method. The promoting effect of medium chain glyce-ride was found to be mainly due to glycerylmonocaprylate and dependent on the concentration of glycerylmonocaprylate. When cefmetazole sodium in medium chain glyceride solution was administered into the rectal lumen of rats, rapid absorption of the drug was observed leading to a residual amount of about 45% at 15 min after administration. The promoting effect of medium chain glyceride was found to be more effective in the rectum than in the small intestine.
- 公益社団法人日本薬学会の論文
著者
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岡田 隆三
(株)東芝研究開発センター
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OKADA Ryuzo
Product Development Laboratories, Sankyo Co., Ltd.
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Okada Ryuzo
Product Development Laboratories Sankyo Co. Ltd.
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Okada Ryuzo
Faculty Of Engineering Osaka University
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Sekine Minoru
Product Development Laboratories Sankyo Co. Ltd.
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AWAZU Shoji
Department of Biopharmaceutics, School of Pharmacy, Tokyo University of Pharmacy and Life Science
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Awazu S
Tokyo Coll. Pharmacy Tokyo Jpn
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Awazu Shoji
Department Of Biopharmaceutics Tokyo College Of Pharmacy
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Awazu Shoji
Deparment Of Biopharmaceutics Tokyo College Of Pharmacy
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Sasahara Kunihiro
Product Development Laboratories Sankyo Co. Ltd.
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