SOLVENT DRAG IN JEJUNAL ABSORPTION OF SALICYLIC ACID AND ANTIPYRINE OBTAINED BY IN SITU SINGLE-PASS RERFUSION METHOD IN RAT
スポンサーリンク
概要
- 論文の詳細を見る
The in situ single-pass perfusion method in an individual rat was developed to discuss the solvent drag in drug intestinal absorption without the individual differences. In this method the apparent water influx (influx') was used as a measure of solvent drag in the same manner as the previous paper^<1)>. Consequently the sieving coefficients of salicylic acid and antipyrine in one rat are not significantly different from one but in the other are significantly smaller than one, resulting in 0.6-0.7 in average. And it was also shown that the reflection from the membrane in the solvent drag can be detected more precisely and efficiently by this method than the recirculating method in the previous paper. The D_2O absorption clearance (CL_<D_2O> was equal to net water flux as estimated theoretically when the D_2O concentration in lumen was equal to that in plasma, indicating that D_2O can be absorbed by water absorption even in the absence of the concentration gradient. Estimating the real water influx from the net water flux obtained under such condition, the minimal contribution ratio of the solvent drag to the total absorption clearance of salicylic acid and antipyrine was calculated to be approximately 12%.
- 公益社団法人日本薬学会の論文
著者
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AWAZU Shoji
東京薬科大学薬学部 薬物動態制御学教室
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Kimura A
Photonic And Wireless Devices Research Laboratories Nec Corporation
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Awazu Shoji
Deparment Of Biopharmaceutics Tokyo College Of Pharmacy
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Karino Akira
Department Of Biopharmaceutics Tokyo College Of Pharmacy:department Of Pharmaceutics Research Center
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Hayashi Masahiro
Department Of Biological Production And Enviromental Science Faculty Of Agriculture The University O
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HIRASAWA TOYOTO
Department of Biopharmaceutics, Tokyo College of Pharmacy
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MURAOKA TOSHIKO
Department of Biopharmaceutics, Tokyo College of Pharmacy
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Hirasawa Toyoto
Department Of Biopharmaceutics Tokyo College Of Pharmacy
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Muraoka Toshiko
Department Of Biopharmaceutics Tokyo College Of Pharmacy:(present Address) Research Laboratory Taish
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Awazu S
Department Of Biopharmaceutics School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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