CHARACTERIZATION OF THE INTERACTION OF ALBUMIN WITH ISOLATED RAT LIVER CELLS TO REVEAL THE MECHANISM OF ALBUMIN-MEDIATED HEPATIC TRANSPORT
スポンサーリンク
概要
- 論文の詳細を見る
The binding of bovine serum albumin (BSA), containing ^<125>I-BSA, to isolated rat hepatocytes was studied over a 300-fold concentration range of BSA to characterize the interaction between albumin and the liver cells in albumin-mediated hepatic transport. The binding of BSA with a high affinity to the cell surface of hepatocytes was not found in the binding behavior. The bound fraction of BSA with hepatocytes was about 1% over those concentration range of BSA.
- 公益社団法人日本薬学会の論文
著者
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HAYASHI Masahiro
Department of Dermatology, Yamagata University School of Medicine
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AWAZU Shoji
Department of Biopharmaceutics, School of Pharmacy, Tokyo University of Pharmacy and Life Science
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MIZUMA Takashi
Department of Biopharmaceutics, Tokyo College of Pharmacy
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HORIE Toshiharu
Departments of Biopharmaceutice, Graduate School of Pharmaceutical Sciences, Chiba University
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AWAZU Shoji
東京薬科大学薬学部 薬物動態制御学教室
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Mizuma Takashi
Department Of Biopharmaceutics Tokyo College Of Pharmacy
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Mizuma Takashi
Department Of Biopharmaceutics And Drug Rational Research Center School Of Pharmacy Tokyo University
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Awazu Shoji
Deparment Of Biopharmaceutics Tokyo College Of Pharmacy
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Hayashi Masahiro
Department Of Biological Production And Enviromental Science Faculty Of Agriculture The University O
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澤山 茂
東京農大 栄養
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Horie Toshiharu
Department Of Biopharmaceutics Graduate School Of Pharmaceutical Sciences Chiba University
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Awazu S
Department Of Biopharmaceutics School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Mizuma Takashi
Department of Applied Chemistry, Faculty of Engineering, Osaka University
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