Improvement of Drug Release Rate from Carbopol 934P Formulation
スポンサーリンク
概要
- 論文の詳細を見る
Carbopol 934P (CP) is a mucoadhesive polymer which has been investigated as a useful adjuvant for bioadhesive drug delivery system. However, since the drug release rate from the solid formulation of CP is slow, it is difficult to take advantage of the polymer's mucoadhesive property in oral administration of fast-acting drugs. In this study, we prepared freeze-dried sodium salt of CP (FNaCP) in order to improve drug release from the formulation of CP. The drug release rate from the formalution of FNaCP was much faster than that of CP : the rate from the formulation of CP in JP XIII 1st fluid (pH 1.2) was faster than in JP XIII 2nd fluid (pH 6.8). To determined the cause of rapid drug release from FNaCP capsules, the change of CP gel properies with pH and ionic strength was investigated. Experimental results indicated that CP forms a swollen gel layer, a drug release barrier between the formulation of CP and the bulk release media. FNaCP was also though to disperse rapidly in the 1st and 2nd fluids without formation of the swollen gel layer. In conclusion, since FNaCP improves the drug release rate from the solid CP formulation, it could be a useful adjuvant of an oral bioadhesive drug delivery system.
- 公益社団法人日本薬学会の論文
- 1998-01-15
著者
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NAKANISHI Takeshi
Department of Applied Physics and DIMES, Delft University of Technology Lorentzweg 1
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HAYASHI Masahiro
Department of Dermatology, Yamagata University School of Medicine
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中西 務
Faculty Of Pharmaceutical Sciences Setsunan University
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Nakanishi T
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Nakanishi Takeshi
Department Of Applied And Bioapplied Chemistry Graduate School Of Engineering Osaka City University
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KAIHO Fusao
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Science University of Tokyo
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Hayashi Masahiro
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Hayashi Masahiro
Department Of Biological Production And Enviromental Science Faculty Of Agriculture The University O
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Kaiho F
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Kaiho Fusao
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Hayashi Masahiro
Department of Absorption and Pharmacokinetics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
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