[2-(ω-Phenylalkyl)phenoxy]alkylamines : Synthesis and Dual Dopamine_2 (D_2) and 5-Hydroxytryptamine_2 (5-HT_2) Receptor Antagonistic Activities

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概要

• 論文の詳細を見る

• A series of [2-(ω-phenylalkyl)phenoxy]alkylamines was synthesized and their 5-hydroxytryptamine_2 (5-HT_2) and/or dopamine_2 (D_2) receptor antagonistic activities were examined in vitro. [2-(4-Phenylbutyl)phenoxy]alkylamines showed strong inhibition of both 5-HT_2 and D_2 receptors. It particular, [2-(4-phenylbutyl)phenoxy]-methylpiperidine derivatives, 10b, 10i and 10q, exhbited potent inhibition. The structure-activity relationships in this series of compounds are discussed.

• 公益社団法人日本薬学会の論文
• 1998-04-15

著者

• Tanaka N

  Department Of Pharmacology School Of Pharmaceutical Sciences Mukogawa Women's University

• Tanaka Naoko

  武庫川女子大学 薬学部薬理学

• Tanaka Naoki

  Medical ProteoScope Co., Ltd.

• Ito R

  Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.

• Ito Rie

  Clinical Pharmacy College Of Pharmacy Nihon University

• 中西 務

  Faculty Of Pharmaceutical Sciences Setsunan University

• Ito Rie

  Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.

• Tanaka N

  School Of Pharmaceutical Sciences Mukogawa Women S University

• Ogawa T

  R & D Division Daiichi Sankyo Co. Ltd.

• GOTO Riki

  Medicinal Chemistry Research Laboratories I, Daiichi Sankyo Co., Ltd.

• HAYAKAWA Miho

  Medicinal Chemistry Research Laboratories II, Daiichi Sankyo Co., Ltd.

• FUJIMOTO Koichi

  Medicinal Chemistry Research Laboratories I, Daiichi Sankyo Co., Ltd.

• OGAWA Taketoshi

  Pharmacology and Molecular Biology Research Laboratories, Sankyo Co., Ltd.

• Goto R

  R & D Division Daiichi Sankyo Co. Ltd.

• Hayakawa Miho

  R & D Division Daiichi Sankyo Co. Ltd.

• Fujimoto K

  R & D Division Daiichi Sankyo Co. Ltd.

• Nishimata Toyoki

  R & D Division Daiichi Sankyo Co. Ltd.

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