TWO NEW POTENT INHIBITORS OF XANTHINE OXIDASE FROM LEAVES OF PERILLA FRUTESCENS BRITTON VAR. ACUTA KUDO
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概要
- 論文の詳細を見る
A known and a new caffeic ester (1 and 2), new inhibitors of xanthine oxidase (XO), were isolated from leaves of Perilla frutescens var. acuta and their structures have been established as (Z, E)-2-(3,4-dihydroxyphenyl)ethenyl ester (1) and (Z, E)-2-(3,5-dihydroxyphenyl)ethenyl ester (2) or 3-(3,4-dihydroxyphenyl)-2-propenoic acid, respectively, based on detailed spectral studies, including 2D COSY, long range COSY, difference NOE, etc. Both caffeic esters strongly inhibited XO in vitro and especially, the inhibition by 1 was as potent as that by allopurinol. The inhibition mode of 1 was also shown to be non-competitive.
- 社団法人日本薬学会の論文
- 1990-06-25
著者
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稲田 昭
Faculty of Pharmaceutical Sciences, Setsunan University
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中西 勤
Faculty of Pharmaceutical Sciences, Setsunan University
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Tanaka Naoko
武庫川女子大学 薬学部薬理学
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阿部 士朗
グンゼ株式会社
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西 正敏
Faculty of Pharmaceutical Sciences, Setsunan University
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稲田 昭
摂南大薬
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中西 勤
摂南大学薬学部
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中西 務
Faculty Of Pharmaceutical Sciences Setsunan University
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小畑 裕士
Research and Development Department
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田辺 伸和
Research and Development Department
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阿部 士朗
Research and Development Department
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若城 道雄
Research and Development Department
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稲田 昭
摂南大学薬学部
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中西 勤
Faculty Of Pharmaceutical Sciences Osaka University
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Tanaka N
School Of Pharmaceutical Sciences Mukogawa Women S University
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西 正敏
Faculty Of Pharmaceutical Sciences Setsunan University
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田辺 伸和
Research And Development Department:gunze Limited
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小畑 裕士
Research And Development Department:gunze Limited
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稲田 昭
Faculty Of Pharmaceutical Sciences Setsunan University
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Nishi M
Faculty Of Pharmaceutical Sciences Setsunan University
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若城 道雄
Research And Development Department:gunze Limited
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