Hinokitiol Induces Differentiation of Teratocarcinoma F9 Cells

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概要

• 論文の詳細を見る

• Hinokitiol, a constituent of the wood of Chamaecyparis taiwanensis, was found to induce differentiation of teratocarcinoma F9 cells. When examined by the agar-overlay method, in which expression of plasminogen activator as a differentiation marker protein was detected, this compound exhibited a dose-and time-dependent induction. Induction of differentiation by hinokitiol occurred irreversibly and required its addition for more than 12h. Among its structure-related compounds tested, tropolone and two colchicine-related compounds exerted potent activities comparable to that of hinokitiol. These findings indicate that free tropolone structure in the molecules plays an essential role in inducing differentiation of F9 cells. Hinokitiol showed a strong inhibitory effect on DNA synthesis in very early stages of culture, suggesting that this effect may be responsible for triggering differentiation of F9 cells.

• 社団法人日本薬学会の論文
• 1995-11-15

著者

• 田中 慶一

  大阪大学 大学院薬学研究科毒性学分野

• 田中 慶一

  Faculty of Nutrition , Kobe-Gakuin University

• 武藤 徳男

  大阪大学薬学部

• 武藤 徳男

  Faculty of Pharmaceutical Sciences, Osaka University

• 堂田 敦義

  Faculty of Pharmaceutical Sciences, Osaka University

• 田中 徹也

  Faculty of Pharmaceutical Sciences, Osaka University

• 伊藤 徳夫

  Faculty of Pharmaceutical Sciences, Osaka University

• 岡部 勝

  Research Institute for Microbial Diseases, Osaka University

• 稲田 昭

  Faculty of Pharmaceutical Sciences, Setsunan University

• 中西 勤

  Faculty of Pharmaceutical Sciences, Setsunan University

• 岡部 勝

  The Research Institute for Microbial Diseases Osaka University

• 武藤 徳男

  県広大生命環境

• 武藤 徳男

  県立広島大学生命環境学部

• 武藤 徳男

  岡山大 薬学部:広島県立大 生物資源

• 稲田 昭

  摂南大薬

• 中西 勤

  摂南大薬

• 中西 勤

  摂南大学薬学部

• 田中 慶一

  大阪大学大学院薬学研究科

• 伊藤 徳夫

  大阪大学大学院薬学研究科毒性学分野

• 稲田 昭

  摂南大学薬学部

• 中西 勤

  Faculty Of Pharmaceutical Sciences Osaka University

• Okabe Masaru

  The Research Institute For Microbial Diseases Osaka University

• 堂田 敦義

  Faculty Of Pharmaceutical Sciences Osaka University

• 稲田 昭

  Faculty Of Pharmaceutical Sciences Setsunan University

• 田中 徹也

  Faculty Of Pharmaceutical Sciences Osaka University

• 岡部 勝

  Research Institute For Microbial Diseases Osaka University

• 田中 慶一

  大阪大学大学院 薬学研究科 毒性学分野

• 武藤 徳男

  県立広島大学生命環境学部・院生命システム科学

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