Biological Properties of the Gastric Juice Inhibitory Substance produced by Streptomyces bottropensis F4708
スポンサーリンク
概要
- 論文の詳細を見る
Gastric juice inhibitory substance (GIS) produced by Streptomyces bottropensis F4708 suppressed carrageenin-induced edema but did not show analgesic effect or influence the circulation system. Effect of adrenergic antagonists on the gastric juice inhibition and lowering of body temperature by GIS was examined. The gastric juice inhibitory activity of GIS was not affected by premedication with Dibenamine or Propranolol. However, the lowering of body temperature by GIS was markedly reinforced by premedication with the antagonists. The dark brown pigment component from GIS was presumed to be a melanin-like substance by comparing its chemical properties with those of DOPA-melanin which exhibited a significant reduction of gastric secretion in rats. Therefore, the gastric juice inhibitory activity of GIS was found to depend on this pigment component in its molecule. Lowering of body temperature of rats was not observed by the administration of DOPA-melanin.
- 公益社団法人日本薬学会の論文
- 1978-03-25
著者
-
武藤 徳男
大阪大学薬学部
-
武藤 徳男
Faculty of Pharmaceutical Sciences, Osaka University
-
小田 泰雄
近畿大学薬学部
-
小田 泰雄
Faculty of Pharmaceutical Sciences, Kinki University, Kowakae
-
青沼 繁
Faculty of Pharmaceutical Sciences of Kinki University
-
小田 泰雄
Faculty Of Pharmaceutical Sciences Kinki University Kowakae
-
三村 務
Faculty of Pharmaceutical Sciences, Osaka University
-
三村 務
大阪大学薬学部
-
青沼 繁
Faculty Of Pharmaceutical Sciences Osaka University
-
田中 直子
Faculty Of Pharmaceutical Sciences Osaka University
-
武藤 徳男
県立広島大学生命環境学部・院生命システム科学
関連論文
- 天然素材からの生理活性物質の開発と機能性評価
- 外因性物質によるメタロチオネインの誘導機構 インターロイキン-6を介する第3の制御系が存在
- Hinokitiol Induces Differentiation of Teratocarcinoma F9 Cells
- ピペリンによるマウスおよびラット小腸粘膜チトクロムP450誘導作用
- ヒガンバナ球根中のマンノース特異的レクチンの単離と性質
- New Lectins from Bulbs of Croccus sativum
- チューリップレクチンのマウス及びヒトリンパ球に対する細胞増殖作用
- Mitogenic Activity of Tulipa gesneriana Lectins on Mouse and Human Lymphocytes
- 関西地区の病院に勤務する薬剤師の職業意識調査
- Studies on Heart. XXIII. Distribution of [1-^C] Acetamidino-antiarrhythmic Peptide (^C-AAP) in Mice
- Induction of Unresponsiveness of Antigen-Specific T Lymphocytes by Oral Administration of Cedar Pollen Extract in Mice
- Studies on Thermophile Products. XI. Biological Effect of Antigen Presenting Inhibitor, Isofatty Acid-Containing Phosphatidylethanolamine, on Mouse Macrophages
- Studies on Thermophile Products. X. Further Biological Properties of Isofatty Acid-Containing Phosphatidylglycerol That Enhances the Induction of Suppressor T Cells
- Studies on Thermophile Products. IX. Isofatty Acid-Containing Phosphatidylglycerol That Enhances the Induction of Concanavalin A-Activated Suppressor T Cells
- Studies on Thermophile Products. VIII. Isolation of Bacillus stearothermophilus UBT8038,a Component That Inhibits Antigen Presentation on Mouse Macrophages
- Inhibitory Effect of Tuna Peptide on Endothelin Production in Cultured Endothelial Cells
- Studies on Thermophile Products. VII. Effect of 1,3-Di-14-methylpentadecanoyl Glycerol and Its Related Isofatty Acids on T Cell Proliferation in Vitro
- Studies on Pharmacological Activation of Human Immunoglobulin G by Chemical Modification and Active Subfragments. XIII. Effect of Carboxamidemethylated Fc Fragment (CM-Fc) on Type II Collagen-Induced Arthritis in DBA/1J Mice
- Abnormal Accumulation of Copper-Metallothionein in the Liver and Kidney of Long-Evans Rats with a Cinnamon-Like Coat Color (LEC Rats)
- Serum Hepatocyte Growth Factor Activity and Hepatocyte Proliferation in Long-Evans with a Cinnamon-Like Coat Color Rats with Hepatic Lesions
- Studies on Pharmacological Activation of Human Immunoglobulin G by Chemical Modification and Active Subfragments. XII. Effect of Carboxamidemethylated Fc Fragment (CM-Fc) from Human Immunoglobulin G on Mixed Lymphocyte Reaction
- Pharmacological Activity of Chemically Modified Subfragment from Human Serum IgG. XI. Increment of Tumor Necrosis Factor (TNF) Activity in Mouse Sera by Carboxamide-Methylated Light Chain
- Studies on Thermophile Products. VI. Activation of Mouse Peritoneal Macrophages by Bis(2-hydroxyethyl) Trisulfide
- Studies on Pharmacological Activation of Human Immunoglobulin G by Chemical Modification and Active Subfragments. X. Effect of Carboxamidemethylated Fc Fragment (CM-Fc) from Human Immunoglobulin G on Delayed Type Hypersensitivity
- Characterization of Capacitation Inhibitory Protein from Rabbit Seminal Plasma : Homology with Human Annexins
- Studies on Pharmacological Activation of Human Serum Immunoglobulin G by Chemical Modification and Active Subfragments. IX. Anti-inflammatory Activity of Completely Alkylated Heavy Chain (C.Fr.I-H)
- Studies on Thermophile Products. V. Immunosuppressive Profile in Vitro of Bacillus stearothermophilus Component, Fr.5-B
- Preparation of Biologically Active and Site Specifically Radioiodinated Recombinant Human Insulin-like Growth Factor-I
- Inhibitory Effects of Bis(2-aminohexyl)disulfide and Its Analogues on Polymorphonuclear Leukocyte Functions in Vitro
- ISOLATION OF A NEW ANTITUMOR SUBSTANCE FROM BACILLUS STEAROTHERMOPHILUS
- Further Studies on the Anti-ulcerogenic Effects of Compound, 2-(E-2-Decenoylamino)ethyl 2-(Cyclohexylethyl) SUlfide
- Effects of 2-(E-2-Decenoylamino)ethyl 2-(Cyclohexylethyl) Sulfide on Varioius Ulcer Models in Rats
- The Effect of a Cystamine Derivative, Bis[2-(E-2-hexenoylamino)ethyl] Disulfide, on Rat Platelet Aggregation
- Further Studies on the Pharmacological Effect of the Anti-inflammatory Compound, Bis[2-(E-2-octenoylamino)ethyl] Disulfide
- 日照条件がアスパラガス若茎のルチン, アスコルビン酸およびクロロフィル含量に及ぼす影響
- 日照条件がアスパラガス若茎の色, ポリフェノール含量および抗酸化活性に及ぼす影響
- ザクロ果汁のエストロゲン様活性
- 有色ダイズの子実特性と抗酸化活性における品種間差異(日本作物学会第216回講演会要旨・資料集)
- 有色米の抗酸化能に関する研究 : 品種間差異と栽培条件の影響(日本作物学会第216回講演会要旨・資料集)
- Inhibitory Effect of Bis(2-aminohexyl) Disulfide and Bis(2-amino-3-phenylpropyl) Disulfide on Several Mouse Inflammations
- 大麦赤紫蘇飲料の摂取がスギおよびヒノキ花粉症患者の症状に及ぼす影響
- オバルブミン感作鼻炎マウスに対する大麦醗酵エキスの効果
- Studies on Heart. XXIV. Inhibitory Effect of Antiarrhythmic Peptide (AAP) on Experimental Thromboses
- Fatty Acids and Sterols of the Tunicate, Salpa thompsoni, from the Antarctic Ocean : Chemical Composition and Hemolytic Activity
- 有色米の抗酸化活性とポリフェノール成分の品種間差異
- マウス由来培養皮膚細胞を用いる真皮モデルの作成ならびに外用剤の安全性評価
- 3. 神経細胞分化におけるビタミンCの増強作用(第123回会議研究発表要旨,ビタミンC研究委員会)
- Effects of the Gastric Juice Inhibitory Substance from Streptomyces bottropensis on Gastric Secretion and Experimental Ulcerations in Rats
- Studies on Thermophile Products. IV. Structural Elucidation of Cytotoxic Substance, BS-1,Derived from Bacillus stearothermophilus
- ISOLATION OF BACILLUS STEAROTHERMOPHILUS CONSTITUENT THAT SUPPRESSES MOUSE MIXED LEUKOCYTE REACTION IN VITRO
- Studies on Chemical Modification of Tulipa gesneriana Lectin
- Interactions of Cadmiun with Yeast Mannans
- 4.酸化ストレス誘導性溶血モデルを用いた安定型アスコルビン酸誘導体の抗酸化活性の検討(第116回会議研究発表要旨,ビタミンC研究委員会)
- Gastric Ulcerogenic and Biological Activities of N-3'a-Propyphenazonyl-2-acetoxybenzamide
- Platelet Anti-aggregant Activity of 2,2-Dimethylthiazolidine Hydrochloride and 2-(4-Hydroxy-3-methoxyphenyl)thiazolidine
- Studies on Heart. XIX. Isolation of an Atrial Peptide that improves the Rhythmicity of Cultured Myocardial Cell Clusters
- Amino Acid Sequence of an Active Fragment, Fr. AA-1,of Salivary Gland Hormone
- 高血圧自然発症ラットにおけるモリンガ葉水抽出物の抗高血圧作用
- Studies on Sperm Capacitation. IX. Movement Characteristics of Spermatozoa in Relation to Capacitation
- The Change of Solubility Properties of Zona Pellucida to Proteases Related to Fertilizability of Mouse Ova in Vitro
- Studies on Biological Activities of Melanin from Marine Animals. V. : Anti-inflammatory Activity of Low-Molecular-Weight Melanoprotein from Squid (Fr. SM II)(Biological)
- Studies on Biological Activities of Melanin from Marine Animals. II. Purification of Melanin from Octopus vulgaris CUVIER and Its Inhibitory Activity on Gastric Juice Secretion in Rats
- Studies on Biological Activities of Melanin from Marine Animals. I. Purification of Melanin from Ommastrephes bartrami LESUEL and Its Inhibitory Activity on Gastric Juice Secretion in Rats
- 病院薬剤師の臨床活動と仕事に対する満足度の関係についての 疫学研究 : 世代による違い
- Synthesis and Antibacterial Activities of Theanine-containing Oligopeptides
- Studies on Pharmacological Activation of Human Serum Immunoglobulin G(IgG) by Chemical Modification and Active Subfragments. VII. Effect of Carboxamidemethylated Fc(CM-Fc) Fragment from Human Serum IgG on Lymphocytes and Macrophages(Pharmacological,Chemic
- Studies on Pharmacological Activation of Human Serum Immunoglobulin G(IgG) by Chemical Modification and Active Subfragments. VI. Anti-allergic Activity of Carboxamidemethylated Fc(CM-Fc) Fragment from Human Serum IgG(Pharmacological,Chemical)
- Inhibitory Effect of Bis[2-(E-2-octenoylamino)ethyl] Disulfide and 2-(E-Octenoylamino)ethyl Carbamoylmethyl Sulfide on Various Inflammation Models(Biological,Chemical)
- Inhibitory Effect of Bis[2-(E-2-alkenoylamino)ethyl] Disulfides and 2-(E-Octenoylamino)ethyl Carbamoylmethyl Sulfides on Carrageenin-Induced Paw Edema in Rats(Biological,Chemical)
- Inhibitory Effect of 2-(E-2-Alkenoylamino)ethyl Alkyl sulfides on Gastric Ulceration in Rats. II. Structure and Activity Relationships of 2-(E-n or Z-n-Decenoylamino)ethyl Alkyl Sulfides
- Isolation and Amino Acid Sequence of Dentinal Fluid Transport-Stimulating Peptide from Rat Parotid Glands
- Studies on Biological Activities of Melanin from Marine Animals. IV. Influence of Fr. SM II (Squid Melanin) on a High Molecular Glycoprotein (Peak I) Level in Rat Gastric Mucosa, and Properties of Peak I as a Gastric Mucosal Defensive Factor
- Streptomyces bottropensis F4708の培養濾液から胃液分泌抑制物質の精製とその性質
- エンド型ヒアルロン酸分解酵素の作用メカニズム:加水分解反応と糖転位反応の解析
- 植物球根レクチンについて
- 陽イオン性界面活性剤との不溶性塩形成を利用するグリコサミノグリカン類の簡易定量
- L-Ascorbic Acid α-Glucoside Formed by Regioselective Transglucosylation with Rat Intestinal and Rice Seed α-Glucosidases : Its Improved Stability and Structure Determination
- Studies on Sperm Capacitation. V. Characterization of Decapacitation Factor from Guinea-pig Spermatozoa
- Effect of Various C_ Fatty Acids, Isopentadecanoic and Isomargaric Acids, on Stabilization of Rat Erythrocytes and Carrageenin-induced Edema
- A Cytolytic Substance, Monopodialysin obtained from a Streptomyces. I. Isolation and Characterization of Monopodialysin produced by Streptomyces aureomonopodiales
- Streptomyces sp.の菌体から抗炎症成分としての脂肪酸類の分離と同定
- Purification and Partial Characterization of the Gastric Ulcer Inhibitory Substance from Culture Filtrate of Bacillus subtilis H
- Identification and Biological Activity of Fatty Acids as a Gastric Secretion Inhibitory Principle from Dried Brewer's Yeast
- Biological Properties of the Gastric Juice Inhibitory Substance produced by Streptomyces bottropensis F4708
- B.subtilis Hの産生する胃酸分泌抑制物質
- Studies on Heart. XX. Further Effects of Bovine Ventricle Protein (BVP) and Antiarrhythmic Peptide (AAP) on Myocardial Cells in Culture
- Effects of Oxytocin on Beating Properties, Myosin ATPase Activity and Macromolecular Synthesis of Rat Myocardial Cells in Culture
- Studies on Heart. XVIII. : Heart Component Influencing the Maintenances of Spreading and Beating of Rat Myocardial Cells in Serum-free Culture
- Studies on Heart. XVII. Effects of Frog Heart Inotropic Substances on Beating of Rat Myocardial Cells in Culture
- Studies on Biological Activities of Melanin from Marine Animals. III. Inhibitory Effect of SM II (Low Molecular Weight Melanoprotein from Squid) on Phenylbutazone-Induced Ulceration in Gastric Mucosa in Rats, and Its Mechanism of Action
- SART stress負荷ラットにおける血圧・血流の異常とそれに及ぼすNeurotropinその他の薬物作用
- 駆血と固定が筋萎縮に与える影響 : ラットを用いた実験的研究
- 虚血再灌流後に起こる骨格筋の変化 : ラットによる実験的研究
- 駆血再灌流後の運動負荷が骨格筋に与える影響 : ラットを用いた実験的研究
- イチゴ葉の抗酸化作用及び抗アレルギー作用
- 食品の免疫調整作用 ([第56回日本体質医学会総会]) -- (シンポジウム 機能食品(サプリメント他)と体質改善)
- キャピラリー電気泳動を用いる一置換アミノベンゼンによる糖類の還元的アミノ化反応の評価
- キャピラリー電気泳動によるN-アセチルノイラミン酸オリゴマーおよびポリマーの高分解能分離
- 医薬品中のグルクロノラクトンおよびグルクロン酸の高速液体クロマトグラフィーによる分析
- Bacillus subtilisによって活性化された牛血清から子宮収縮活性ポリペプチドの単離とその性質