Mitogenic Activity of Tulipa gesneriana Lectins on Mouse and Human Lymphocytes

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Tulipa gesneriana lectin-erythrocyte (TGL-E) which agglutinates mouse erythrocytes showed a potent mitogenic activity on mouse spleen cells and human peripheral blood lymphocytes, however, TGL-E had only slight mitogenic activity on mouse thymus cells. Its subunit α with a molecular weight (MW) of about 26000 showed a potent mitogenic activity as did that of native lectin, but subunit β with a MW of about 14000 showed no activity, indicating that the mitogenic activity of TGL-E originates from subunit α. TGL-E stimulated T cell enriched spleen cells which passed through a nylon column, but not spleen cells from a nude mouse or spleen cells treated with anti-Thy 1・2 antibody and complement. Thus, TGL-E stimulates only mouse T cells but not B cells. the other lectin in tulip bulbs, Tulipa gesneriana lectin-yeast showed no mitogenic activity on mouse spleen, thymus cells or human paripheral blood lymphocytes.
社団法人日本薬学会の論文
1991-12-25

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