Studies on Biological Activities of Melanin from Marine Animals. I. Purification of Melanin from Ommastrephes bartrami LESUEL and Its Inhibitory Activity on Gastric Juice Secretion in Rats
スポンサーリンク
概要
- 論文の詳細を見る
Crude squid melanin obtained from ink bags of Ommastrephes bartrami LESUEL was found to exhibit a strong inhibitory effect on gastric secretion in rats. The crude melanin was separated into high molecular fraction SM I (mol. wt.>160000) and low molecular fraction SM II (average mol. wt. ca. 39000) by gel filtration on a Sephadex G-100 column, and Fr. SM II showed a stronger biological activity. Fr. SM II contained a melanoprotein composed of melanin pigment 90%, protein 5.8% and carbohydrate 0.8%, and significantly decreased gastric secretion at the dosage of 1 mg/kg, i.p. or i.v. Fr. SM II also prevented ulcer formation in pylorus-ligated rats and aspirin-induced ulcer.
- 社団法人日本薬学会の論文
- 1982-04-25
著者
-
青沼 繁
Faculty of Pharmaceutical Sciences of Kinki University
-
三村 務
Faculty of Pharmaceutical Sciences, Osaka University
-
三村 務
大阪大学薬学部
-
青沼 繁
Faculty Of Pharmaceutical Sciences Osaka University
-
前田 和宏
Faculty Of Pharmaceutical Sciences Osaka University
-
佐竹 幹雄
日本水産
-
佐竹 幹雄
The Central Research Laboratory of Nippon Suisan Co., Ltd.
-
藤田 孝夫
The Central Research Laboratory of Nippon Suisan Co., Ltd.
-
針山 久代
Faculty of Pharmaceutical Science, Osaka University
-
針山 久代
Faculty Of Pharmaceutical Science Osaka University
-
藤田 孝夫
The Central Research Laboratory of Nippon Suisan Co.
関連論文
- Mitogenic Activity of Tulipa gesneriana Lectins on Mouse and Human Lymphocytes
- ^I-標識Monoiodohistidineを利用したカルノシンおよび関連N-α-Aminoacylhistidineの生合成 : 心臓の研究 第11報
- カルノシンおよびアンゼリンの前駆物質としてのβ-L-Aspartyl-L-histidineの検討 : 心臓の研究 第10報
- Studies on Heart. XXIII. Distribution of [1-^C] Acetamidino-antiarrhythmic Peptide (^C-AAP) in Mice
- Pharmacological Activity of Chemically Modified Subfragment from Human Serum IgG. XIV. Inhibitory Effect of Carboxamide-Methylated Light Chain (G_1L) on Tyrosine Phosphorylation and Tumor Necrosis Factor-α Production from Murine Macrophages Stimulated by
- Induction of Unresponsiveness of Antigen-Specific T Lymphocytes by Oral Administration of Cedar Pollen Extract in Mice
- Studies on Thermophile Products. XI. Biological Effect of Antigen Presenting Inhibitor, Isofatty Acid-Containing Phosphatidylethanolamine, on Mouse Macrophages
- Studies on Thermophile Products. X. Further Biological Properties of Isofatty Acid-Containing Phosphatidylglycerol That Enhances the Induction of Suppressor T Cells
- Studies on Thermophile Products. IX. Isofatty Acid-Containing Phosphatidylglycerol That Enhances the Induction of Concanavalin A-Activated Suppressor T Cells
- Studies on Thermophile Products. VIII. Isolation of Bacillus stearothermophilus UBT8038,a Component That Inhibits Antigen Presentation on Mouse Macrophages
- Inhibitory Effect of Tuna Peptide on Endothelin Production in Cultured Endothelial Cells
- Studies on Thermophile Products. VII. Effect of 1,3-Di-14-methylpentadecanoyl Glycerol and Its Related Isofatty Acids on T Cell Proliferation in Vitro
- Studies on Pharmacological Activation of Human Immunoglobulin G by Chemical Modification and Active Subfragments. XIII. Effect of Carboxamidemethylated Fc Fragment (CM-Fc) on Type II Collagen-Induced Arthritis in DBA/1J Mice
- Abnormal Accumulation of Copper-Metallothionein in the Liver and Kidney of Long-Evans Rats with a Cinnamon-Like Coat Color (LEC Rats)
- Serum Hepatocyte Growth Factor Activity and Hepatocyte Proliferation in Long-Evans with a Cinnamon-Like Coat Color Rats with Hepatic Lesions
- Studies on Pharmacological Activation of Human Immunoglobulin G by Chemical Modification and Active Subfragments. XII. Effect of Carboxamidemethylated Fc Fragment (CM-Fc) from Human Immunoglobulin G on Mixed Lymphocyte Reaction
- Pharmacological Activity of Chemically Modified Subfragment from Human Serum IgG. XI. Increment of Tumor Necrosis Factor (TNF) Activity in Mouse Sera by Carboxamide-Methylated Light Chain
- Studies on Thermophile Products. VI. Activation of Mouse Peritoneal Macrophages by Bis(2-hydroxyethyl) Trisulfide
- Studies on Pharmacological Activation of Human Immunoglobulin G by Chemical Modification and Active Subfragments. X. Effect of Carboxamidemethylated Fc Fragment (CM-Fc) from Human Immunoglobulin G on Delayed Type Hypersensitivity
- Characterization of Capacitation Inhibitory Protein from Rabbit Seminal Plasma : Homology with Human Annexins
- Studies on Pharmacological Activation of Human Serum Immunoglobulin G by Chemical Modification and Active Subfragments. IX. Anti-inflammatory Activity of Completely Alkylated Heavy Chain (C.Fr.I-H)
- Studies on Thermophile Products. V. Immunosuppressive Profile in Vitro of Bacillus stearothermophilus Component, Fr.5-B
- Pharmacological Activity of Chemically Modified Subfragment from Human Serum IgG. XIV. Inhibitory Effect of Carboxamide-Methylated Light Chain (G_1L) on Tyrosine Phosphorylation and Tumor Necrosis Factor-α Production from Murine Macrophages Stimulated by
- Preparation of Biologically Active and Site Specifically Radioiodinated Recombinant Human Insulin-like Growth Factor-I
- Inhibitory Effects of Bis(2-aminohexyl)disulfide and Its Analogues on Polymorphonuclear Leukocyte Functions in Vitro
- ISOLATION OF A NEW ANTITUMOR SUBSTANCE FROM BACILLUS STEAROTHERMOPHILUS
- Further Studies on the Anti-ulcerogenic Effects of Compound, 2-(E-2-Decenoylamino)ethyl 2-(Cyclohexylethyl) SUlfide
- Effects of 2-(E-2-Decenoylamino)ethyl 2-(Cyclohexylethyl) Sulfide on Varioius Ulcer Models in Rats
- The Effect of a Cystamine Derivative, Bis[2-(E-2-hexenoylamino)ethyl] Disulfide, on Rat Platelet Aggregation
- Further Studies on the Pharmacological Effect of the Anti-inflammatory Compound, Bis[2-(E-2-octenoylamino)ethyl] Disulfide
- Inhibitory Effect of Bis(2-aminohexyl) Disulfide and Bis(2-amino-3-phenylpropyl) Disulfide on Several Mouse Inflammations
- Studies on Heart. XXIV. Inhibitory Effect of Antiarrhythmic Peptide (AAP) on Experimental Thromboses
- Isopropylantipyrine誘導体特にEphedrine-Isopropylantipyrineの生物活性とその^3H標識化合物の代謝
- Fatty Acids and Sterols of the Tunicate, Salpa thompsoni, from the Antarctic Ocean : Chemical Composition and Hemolytic Activity
- Bacillus属細菌の産生する生理活性物質の研究(第6報)サーファクチンの生体膜溶解活性に対する血清カルシウム低下活性リポ蛋白質α-Iの阻害効果
- Effects of the Gastric Juice Inhibitory Substance from Streptomyces bottropensis on Gastric Secretion and Experimental Ulcerations in Rats
- Effect of Uterine Environment and Uterine Extract on Guinea Pig Sperm Metabolism
- Studies on Thermophile Products. IV. Structural Elucidation of Cytotoxic Substance, BS-1,Derived from Bacillus stearothermophilus
- ISOLATION OF BACILLUS STEAROTHERMOPHILUS CONSTITUENT THAT SUPPRESSES MOUSE MIXED LEUKOCYTE REACTION IN VITRO
- Studies on Chemical Modification of Tulipa gesneriana Lectin
- Interactions of Cadmiun with Yeast Mannans
- Gastric Ulcerogenic and Biological Activities of N-3'a-Propyphenazonyl-2-acetoxybenzamide
- Platelet Anti-aggregant Activity of 2,2-Dimethylthiazolidine Hydrochloride and 2-(4-Hydroxy-3-methoxyphenyl)thiazolidine
- Studies on Heart. XIX. Isolation of an Atrial Peptide that improves the Rhythmicity of Cultured Myocardial Cell Clusters
- Amino Acid Sequence of an Active Fragment, Fr. AA-1,of Salivary Gland Hormone
- Studies on Sperm Capacitation. IX. Movement Characteristics of Spermatozoa in Relation to Capacitation
- The Change of Solubility Properties of Zona Pellucida to Proteases Related to Fertilizability of Mouse Ova in Vitro
- D-Cysteinolic Acidの薬理活性
- Studies on Biological Activities of Melanin from Marine Animals. V. : Anti-inflammatory Activity of Low-Molecular-Weight Melanoprotein from Squid (Fr. SM II)(Biological)
- 南極産オキアミから胃液分泌抑制活性を有する核酸分画の分離
- Studies on Biological Activities of Melanin from Marine Animals. II. Purification of Melanin from Octopus vulgaris CUVIER and Its Inhibitory Activity on Gastric Juice Secretion in Rats
- Studies on Biological Activities of Melanin from Marine Animals. I. Purification of Melanin from Ommastrephes bartrami LESUEL and Its Inhibitory Activity on Gastric Juice Secretion in Rats
- Bacillus属細菌の産生する生理活性物質の研究(第5報)B.subtilis Kにより産生される血清カルシウム低下性物質α因子より界面活性成分と脂質の除去
- Studies on Pharmacological Activation of Human Serum Immunoglobulin G(IgG) by Chemical Modification and Active Subfragments. VII. Effect of Carboxamidemethylated Fc(CM-Fc) Fragment from Human Serum IgG on Lymphocytes and Macrophages(Pharmacological,Chemic
- Studies on Pharmacological Activation of Human Serum Immunoglobulin G(IgG) by Chemical Modification and Active Subfragments. VI. Anti-allergic Activity of Carboxamidemethylated Fc(CM-Fc) Fragment from Human Serum IgG(Pharmacological,Chemical)
- Inhibitory Effect of Bis[2-(E-2-octenoylamino)ethyl] Disulfide and 2-(E-Octenoylamino)ethyl Carbamoylmethyl Sulfide on Various Inflammation Models(Biological,Chemical)
- Inhibitory Effect of Bis[2-(E-2-alkenoylamino)ethyl] Disulfides and 2-(E-Octenoylamino)ethyl Carbamoylmethyl Sulfides on Carrageenin-Induced Paw Edema in Rats(Biological,Chemical)
- Ephedrine-Isopropylantipyrineの浮腫および血管透過性亢進に対する影響
- ワクシニアウイルスで感染した家兎皮膚組織中の生物活性物質の研究特に胃酸分泌抑制物質の分離とその性質
- Inhibitory Effect of 2-(E-2-Alkenoylamino)ethyl Alkyl sulfides on Gastric Ulceration in Rats. II. Structure and Activity Relationships of 2-(E-n or Z-n-Decenoylamino)ethyl Alkyl Sulfides
- Effect of N-3-(4-Hydroxyphenyl)propionyl Pro-Pro-Gly-Ala-Gly on Calcium-Induced Arrhythmias
- Inhibitory Effect of 2-(E-2-Alkenoylamino)ethyl Alkyl Sulfides on Gastric Ulceration in Rats. I. Effect of 2-(E-2-Alkenoylamino)ethyl Carbamoylmethyl Sulfides on Gastric Secretion and Various Ulceration Models in Rats(Pharmacological,Chemical)
- Isolation and Amino Acid Sequence of Dentinal Fluid Transport-Stimulating Peptide from Rat Parotid Glands
- Studies on Biological Activities of Melanin from Marine Animals. IV. Influence of Fr. SM II (Squid Melanin) on a High Molecular Glycoprotein (Peak I) Level in Rat Gastric Mucosa, and Properties of Peak I as a Gastric Mucosal Defensive Factor
- Streptomyces bottropensis F4708の培養濾液から胃液分泌抑制物質の精製とその性質
- ヒト血清IgGの化学修飾による新規活性の誘導と医薬品開発への応用
- 新しい精子機能検査アクロビーズテストによる男性不妊症の診断 : シンポジウム : 泌尿器科癌の化学療法における biochemical modulation の現況 : 第42回中部総会
- The Inhibitory Effect of Bis[2-[(E)-2-octenoylamino]ethyl] Disulfide on the Cyclooxygenase Pathway
- Purification and Characterization of a New Peptide-Mannan, SP-I, as a Gastric Secretion-Inhibitory Principle from Autolysate of Brewer's Yeast
- Bacillus属細菌の産生する生理活性物質の研究(第4報) : B.subtilis Kの培養濾液から得られるガマ心臓機能促進成分について
- マウス体外受精に関する基礎的検討(第1報)
- Studies on Sperm Capacitation. V. Characterization of Decapacitation Factor from Guinea-pig Spermatozoa
- Dehydrocholyl-methionineおよびそのEthyl Esterの肝臓機能に及ぼす態度
- コール酸, テヒドロコール酸のアミノ酸抱合体の実験的肝障害に及ぼす効果
- 1-^C-Palmitic Acidと1-^C-Myristic Acidの正常およびGranuloma Pouchラットにおける生体内分布
- Effect of Various C_ Fatty Acids, Isopentadecanoic and Isomargaric Acids, on Stabilization of Rat Erythrocytes and Carrageenin-induced Edema
- A Cytolytic Substance, Monopodialysin obtained from a Streptomyces. I. Isolation and Characterization of Monopodialysin produced by Streptomyces aureomonopodiales
- ラット赤血球膜安定化およびカラゲニン浮腫に対する脂肪酸類の影響
- Streptomyces sp.の菌体から抗炎症成分としての脂肪酸類の分離と同定
- Purification and Partial Characterization of the Gastric Ulcer Inhibitory Substance from Culture Filtrate of Bacillus subtilis H
- 家兔皮膚炎症組織中の抗潰瘍性蛋白質の研究(第2報)Arthus反応組織中より胃液分泌抑制およびカラゲニン浮腫抑制作用を有する物質の分離, 精製
- カルノシンおよびアンゼリンに関連するβ-Alanyl-peptidesの生理化学的検討
- Identification and Biological Activity of Fatty Acids as a Gastric Secretion Inhibitory Principle from Dried Brewer's Yeast
- Biological Properties of the Gastric Juice Inhibitory Substance produced by Streptomyces bottropensis F4708
- B.subtilis Hの産生する胃酸分泌抑制物質
- 家兎皮膚炎症組織中の抗潰瘍性蛋白質の研究(第3報)ワクシニアウイルス感染組織中の抗潰瘍活性ペプタイド(Gly-Ser-His-Lys)
- 245)心臓の研究(第22報) : 心臓ペプタイド(AAP)の実験的不整脈に対する作用 : 日本循環器学会第54回近畿地方会
- 心臓の研究(第22報)心臓ペプタイド(AAP)の薬物誘発不整脈に対する抑制作用
- Studies on Heart. XX. Further Effects of Bovine Ventricle Protein (BVP) and Antiarrhythmic Peptide (AAP) on Myocardial Cells in Culture
- Effects of Oxytocin on Beating Properties, Myosin ATPase Activity and Macromolecular Synthesis of Rat Myocardial Cells in Culture
- Studies on Heart. XVIII. : Heart Component Influencing the Maintenances of Spreading and Beating of Rat Myocardial Cells in Serum-free Culture
- Studies on Heart. XVII. Effects of Frog Heart Inotropic Substances on Beating of Rat Myocardial Cells in Culture
- Studies on Biological Activities of Melanin from Marine Animals. III. Inhibitory Effect of SM II (Low Molecular Weight Melanoprotein from Squid) on Phenylbutazone-Induced Ulceration in Gastric Mucosa in Rats, and Its Mechanism of Action
- Bacillus属細菌の産生する生理活性物質の研究(第3報) : B.subtilis Kのにより産生される家兎血清カルシウム低下性物質の単離とその性質
- Isolation and Identification of Hypotensive Principles in Red-Mold Rice(Biological)
- Bacillus subtilisによって活性化された牛血清から子宮収縮活性ポリペプチドの単離とその性質
- 青沼繁先生を偲んで
- 7.β-SitosterolならびにCalciferolと2,4-Dinitrofluorobenzeneとの反応について(第44回協議会研究発表要旨)
- ビタミンB_1ならびにピリミジン誘導体と2,4-DINITROFLUOROBENZENEとの反応について
- 11.ビタミンB_1およびピリミジン体と2,4-Dinitrofluorobenzeneとの反応(第80回協議会研究発表要旨)