カルノシンおよびアンゼリンの前駆物質としてのβ-L-Aspartyl-L-histidineの検討 : 心臓の研究第10報

概要

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DL-Aspartic acid [3-^<14>C] is distributed in approximately 10^<-2>% (24-hour value) in the 80% ethanol extracted fraction of various organs of the rat, the distribution concentrated mostly in the spleen. Incorporation of labeled aspartic acid into caronsine and anserine, and the dilution value of specific activities are about the same as in the case of β-alanine, and incorporation of radioactivity is greater into carnosine than into anserine. Under the same conditions, incorporation of L-leucine [U-^<14>C] into carnosine and anserine not taking place, incorporation of aspartic acid and β-alanine into these peptises are specific. β-Aspartylhistidine is decarboxylated by the carnosine-synthesizing enzyme system but there is no formation of carnosine or anserine, and β-aspartylhistidine is found to be hydrolyzed and further decomposed. β-Aspartylhistidine decreases the amplitude of systolic heart beat of excised toad heart but does not affect peripheral blood, differing from carnosine, and antagonizes oxytocin action in uterine muscle. From these experimental evidences, it is concluded that aspartic acid is a biological precursor of carnosine and anserine, but there is little possibility than β-aspartylhistidine serves as a direct precursor of carnosine.
社団法人日本薬学会の論文
1968-01-25