心臓の研究(第22報)心臓ペプタイド(AAP)の薬物誘発不整脈に対する抑制作用

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The effect of an atrial peptide, Gly-Pro-4Hyp-Gly-Ala-Gly (AAP), on several druginduced arrhythmias in anesthetized dogs, rats and mice was investigated together with its effect on the related functions. AAP (10 mg/kg, i.v.) significantly reversed the persistent arrhythmias consisting of atrio-ventricular (A-V) block, ectopic beat and/or ventricular tachycardia induced by aconitine pretreatment, to normal sinus rhythm for a while, and evidently prevented development of ventricular fibrillation in dogs and rats. AAP (10,25 mg/kg, i.v.) significantly prolonged the time until onset of A-V block or ectopic beat and the time until onset of ventricular tachycardia induced by aconitine infusion in mice. This peptide (10 mg/kg, i.v.) significantly prolonged the onset time of A-V block or ectopic beat induced by CaCl_2 infusion and the time until ventricular fibrillation induced by ouabain infusion in mice, and significantly shortened the duration of arrhythmia induced by ADP in rats, but did not affect the mouse epinephrine-induced arrhythmia. The peptide (25 mg/kg, i.v.) was found to prolong significantly the QTc interval and to have no effect on the PQ interval, heart rate, respiratory rate and blood pressure in dogs. AAP (1 g/kg. i.v., i.p. and p.o.) did not show the acute toxicity in mice. AAP was a chemically new type of antiarrhythmic substance with very little side effect and low toxicity, possessing the action intensity almost equal to quinidine.
公益社団法人日本薬学会の論文
1983-06-25

心臓の研究(第22報)心臓ペプタイド(AAP)の薬物誘発不整脈に対する抑制作用

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