Pharmacological Activity of Chemically Modified Subfragment from Human Serum IgG. XI. Increment of Tumor Necrosis Factor (TNF) Activity in Mouse Sera by Carboxamide-Methylated Light Chain
スポンサーリンク
概要
- 論文の詳細を見る
Intravenous administration of the carboxamide-methylated light chain (G_1L) from human serum IgG induced tumor necrosis factor (TNF), one of the inflammatory cytokines, in the serum of mice. Human serum IgG, however, showed no induction of TNF in the serum. G_1L showed a potent anti-inflammatory effect in carrageenin-induced paw edema, and the anti-inflammatory effect of G_1L was significantly blocked by the concomitant administration of anti-TNF antiserum, but TNF alone had no anti-inflammatory effect.
- 社団法人日本薬学会の論文
- 1994-02-15
著者
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伊藤 正明
Faculty Of Pharmaceutical Sciences Osaka University
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鈴木 信孝
Faculty Of Pharmaceutical Sciences Osaka University
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小濱 靖弘
大阪大学 薬 微薬品化
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辻川 和丈
阪大薬
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小濱 靖弘
Faculty of Pharmaceutical Sciences, Osaka University
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辻川 和丈
Faculty of Pharmaceutical Sciences, Osaka University
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三村 務
Faculty of Pharmaceutical Sciences, Osaka University
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杉山 哲也
Faculty of Pharmaceutical Sciences, Osaka University
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鈴木 孝
Faculty of Pharmaceutical Sciences, Osaka University
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杉山 哲也
Faculty Of Pharmaceutical Sciences Osaka University
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三村 務
大阪大学薬学部
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小浜 靖弘
大阪大学薬学部
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Tanaka Ken-ichiro
Faculty Of Pharmaceutical Sciences Okayama University
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Mimura T
Osaka Univ. Osaka Jpn
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鈴木 孝
Faculty Of Pharmaceutical Sciences Osaka University
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辻川 和丈
Faculty of Pharmaceutical Sciences, Okayama University
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