Studies on Biological Activities of Melanin from Marine Animals. V. : Anti-inflammatory Activity of Low-Molecular-Weight Melanoprotein from Squid (Fr. SM II)(Biological)

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概要

• 論文の詳細を見る

• Low-molecular-weight melanoprotein obtained from Ommastrephes bartrami LOSUEL (Fr. SM II) was subjected to an anti-inflammatory screening procedure and was shown to have a potent inhibitory activity against carrageenin-induced rat paw edema. Fr. SM II was then studied with various acute inflammatory models and appeared to suppress the enhanced capillary permeability of mouse ear induced by xylene and the acceleration of vascular permeability induced by compound 48/80. Using the carboxymethylcellulose pouch method, both leucocyte emigration and protein exudation into the pouch fluid were potently inhibited by Fr. SM II. Fr. SM II was also effective in subacute inflammation induced by the felt pellet and the croton oil granuloma pouch methods. Thus, in addition to its anti-ulcerogenic activity, Fr. SM II also has anti-inflammatory activity.

• 社団法人日本薬学会の論文
• 1987-03-25

著者

• 伊東 進

  阪大・薬

• 小濱 靖弘

  Faculty of Pharmaceutical Sciences, Osaka University

• 辻川 和丈

  Faculty of Pharmaceutical Sciences, Osaka University

• 三村 務

  Faculty of Pharmaceutical Sciences, Osaka University

• 伊東 進

  Faculty of Pharmaceutical Sciences, Osaka University

• 岡部 勝

  Faculty of Pharmaceutical Sciences, Osaka University

• 中島 博志

  Faculty of Pharmaceutical Sciences, Osaka University

• 中島 博志

  Faculty Of Pharmaceutical Sciences Osaka University

• 三村 務

  大阪大学薬学部

• 岡部 勝

  大阪大薬学部

• Tanaka K

  Department Of Molecular Engineering Graduate School Of Engineering Kyoto University

• Tanaka Ken-ichiro

  Faculty Of Pharmaceutical Sciences Okayama University

• 佐竹 幹雄

  日本水産

• 佐竹 幹雄

  Japan and The Central Research Laboratory of Nippon Suisan Co., Ltd.

• Itoh S

  Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osada Univers

• Itoh S

  Showa Denko Co. Tokyo Jpn

• 岡部 勝

  大阪大学 薬

• 辻川 和丈

  Faculty of Pharmaceutical Sciences, Okayama University

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