The Inhibitory Effect of Bis[2-[(E)-2-octenoylamino]ethyl] Disulfide on the Cyclooxygenase Pathway
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概要
- 論文の詳細を見る
Bis[2-[(E)-2-octenoylamino]ethyl] disulfide (compd. I-3) inhibited collagen- and arachidonic acid-induced rat platelet aggregation, although not adenosine 5'-diphosphate (ADP)-induced rat platelet aggregation.Based on these results, we then investigated the inhibitory effect of compd. I-3 on thromboxane B_2 formation from arachidonic acid in rat platelets, and prostaglandin I_2 formation in rat aortae. Compound I-3 inhibited both thromboxane B_2 and prostaglandin I_2 formation, suggesting that it has an inhibitory effect on cyclooxygenase. The inhibitory effect of compd. I-3 was confirmed in experiments using a crude preparation of sheep seminal vesicle microsomal prostaglandin synthetase. These findings suggested that compd. I-3 has an inhibitory effect on cyclooxygenase activity, like non-steroidal anti-inflammatory drugs.
- 公益社団法人日本薬学会の論文
- 1989-03-25
著者
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横山 和正
Central Research Laboratory, Green Cross Corporation
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横山 和正
ミドリ十字、中研
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小濱 靖弘
大阪大学 薬 微薬品化
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辻川 和丈
阪大薬
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辻川 和丈
Faculty of Pharmaceutical Sciences, Osaka University
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三村 務
Faculty of Pharmaceutical Sciences, Osaka University
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岡部 勝
Faculty of Pharmaceutical Sciences, Osaka University
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春山 宗忠
Faculty of Pharmaceutical Sciences, Osaka University
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岩井 正和
Central Reserach Laboratories, The Green Cross Corporation
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中島 博志
Faculty of Pharmaceutical Sciences, Osaka University
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中島 博志
Faculty Of Pharmaceutical Sciences Osaka University
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三村 務
大阪大学薬学部
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岡部 勝
大阪大薬学部
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岩井 正和
Central Research Laboratories The Green Cross Corporation
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安田 尚弘
Faculty of Pharmaceutical Sciences, Osaka University
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春山 宗忠
Faculty Of Pharmaceutical Sciences Osaka University
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安田 尚弘
Faculty Of Pharmaceutical Sciences Osaka University
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岡部 勝
大阪大学 薬
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横山 和正
Central Research Laboratories The Green Cross Corporation
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辻川 和丈
Faculty of Pharmaceutical Sciences, Okayama University
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