Comparison of Efficacy, Toxicity adn Pharmacokinetics of Free Adriamycin and Adriamycin Linked to Oxidized Dextran in Rats

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概要

• 論文の詳細を見る

• Adriamycin linked to oxidized dextran (ADM-OXD) via Schiff's base formation was compared wiht free adriamycin with regard to antiumor activity, acute toxicity and plasma pharmacokinetics in rats following i.v. administration. ADM-OXD showed higher activity against Walker carcinosarcoma 256 than free adriamycin. On the other hand, the acute toxicity of ADM-OXD was about three times less than that of free adriamycin. In contrast to free adriamycin, a very high plasma level of adriamycin was found after i.v. administration of ADM-OXD. The area under the plasma concentration curve with ADM-OXD was about 160-fold higher than with free adriamycin. Thus, the improvement fo the therapeutic index in the case of ADM-OXD might be due to the difference in the disposition of ADM-OXD and free adriamycin in rats.

• 公益社団法人日本薬学会の論文
• 1989-06-25

著者

• 横山 和正

  Central Research Laboratory, Green Cross Corporation

• 横山 和正

  株式会社ミドリ十字中央研究所

• 山内 紘一

  Central Research Laboratory, The Green Cross Corporation

• 上田 泰生

  株式会社ミドリ十字 中央研究所

• 棟近 公司

  Central Research Laboratories, The Green Cross Corporation

• 上田 泰生

  Central Research Laboratories, The Green Cross Corporation

• 菊川 彰人

  Central Research Laboratories, The Green Cross Corporation

• 加納 義明

  Central Research Laboratories, The Green Cross Corporation

• 菊川 彰人

  Central Research Laboratories The Green Cross Corporation

• 横山 和正

  Central Research Laboratories The Green Cross Corporation

• 山内 紘一

  Central Research Laboratories The Green Cross Corporation

• 棟近 公司

  Central Research Laboratories The Green Cross Corporation

• 加納 義明

  Central Research Laboratories The Green Cross Corporation

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