Inhibitory Activities and Inhibition Specificities of Caffeic Acid Derivatives and Related Compounds toward 5-Lipoxygenase
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概要
- 論文の詳細を見る
Various caffeic acid derivatives were synthesized, and their effects on 5-lipoxygenase (5-LO), 12-lipoxygenase (12-LO) and prostaglandin (PG) synthase activities were investigated. Among them, caffeic acid octyl amide (5) and 1-(3,4-dihydroxyphenyl)-1-octen-3-one (11) showed very potent inhibitory activities toward 5-LO with IC_<50> values of 4.2×10^<-8> and 3.5×10^<-8> M, respectively. They were very selective inhibitors for 5-LO. Compound 11 showed noncompetitive inhibition, and the two adjacent hydroxy groups attached to the benzene ring, as well as the hydrophobic alkyl side chain, were required for its strong binding to 5-LO.
- 公益社団法人日本薬学会の論文
- 1989-04-25
著者
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横山 和正
Central Research Laboratory, Green Cross Corporation
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横山 和正
株式会社ミドリ十字中央研究所
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杉浦 正典
(株)ミドリ十字中央研究所
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深谷 力
Research Division The Green Cross Corporation
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杉浦 正典
ミドリ十字中央研究所
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内藤 洋一郎
Central Research Laboratories, Green Cross Corporation
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深谷 力
Central Research Laboratories, Green Cross Corporation
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杉浦 正典
Central Research Laboratories, Green Cross Corporation
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山浦 康成
Central Research Laboratories, Green Cross Corporation
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山浦 康成
Central Research Laboratories Green Cross Corporation
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横山 和正
株式会社ミドリ十字 中央研究所
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横山 和正
Central Research Laboratories The Green Cross Corporation
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内藤 洋一郎
Central Research Laboratories Green Cross Corporation:department Of Agricultural Chemistry Faculty O
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