Effect of N-3-(4-Hydroxyphenyl)propionyl Pro-Pro-Gly-Ala-Gly on Calcium-Induced Arrhythmias
スポンサーリンク
概要
- 論文の詳細を見る
The present investigation was done to examine whether or not the presence of hydroxyproline in N-3-(4-hydroxyphenyl)propionyl Pro-Hyp-Gly-Ala-Gly (HP-5) is essential for the antiarrhythmic activity. Pretreatment of mice with 10 mg/kg of [Pro^2]-HP-5-provided significantly better protection against calcium-induced arrhythmias than did pretreatment with HP-5. Thus, the prolyl residue was more favorable than the hydroxyprolyl residue for antiarrhythmic activity of these analogues.
- 公益社団法人日本薬学会の論文
- 1988-11-25
著者
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横山 和正
Central Research Laboratory, Green Cross Corporation
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小浜 靖弘
Faculty of Pharmaceutical Sciences, Osaka University
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小濱 靖弘
大阪大学 薬 微薬品化
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三村 務
Faculty of Pharmaceutical Sciences, Osaka University
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岡部 勝
Faculty of Pharmaceutical Sciences, Osaka University
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横山 和正
株式会社ミドリ十字中央研究所
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渡辺 正弘
Central Reserach Laboratories, The Green Cross Corporation
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三村 務
大阪大学薬学部
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岡部 勝
大阪大薬学部
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小浜 靖弘
大阪大学薬学部
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深谷 力
Research Division The Green Cross Corporation
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桑原 栄樹
Faculty of Pharmaceutical Sciences, Osaka University
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山本 浩二
Faculty of Pharmaceutical Sciences, Osaka University
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山本 浩二
Faculty Of Pharmaceutical Sciences Osaka University
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深谷 力
Central Research Laboratories, Green Cross Corporation
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岡部 勝
大阪大学 薬
-
横山 和正
株式会社ミドリ十字 中央研究所
-
横山 和正
Central Research Laboratories The Green Cross Corporation
-
桑原 栄樹
Faculty Of Pharmaceutical Sciences Osaka University
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