Dexamethasone 21-Acetateの光反応
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概要
- 論文の詳細を見る
The photochemical reaction of dexamethasone 21-acetate (1) was studied to explore the influence of 11β-hydroxy group on the photochemical process of a cross-conjugated dienone system. Irradiation of 1 in methanol gave the lumi-product (2) and its two isomers, 1β, 11β-epoxy-9α-fluoro-17α-21-dihydroxy-16α-methyl-10α-pregn-4-ene-2,20-dione 21-acetate (3) and 2,5-cyclo-1β, 11β-epoxy-9α-fluoro-2β, 17α, 21-trihydroxy-16α-methyl-5β, 10α-pregn-3-en-20-one 21-acetate (4). Compound 2 was proved to be an intermediate for 3 and 4.
- 公益社団法人日本薬学会の論文
- 1985-11-25
著者
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横山 和正
ミドリ十字、中研
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横山 和正
株式会社ミドリ十字中央研究所
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深谷 力
Research Division The Green Cross Corporation
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荒川 良夫
Central Research Laboratories, The Green Cross Corporation
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荒川 良夫
ミドリ十字中央研究所
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深谷 力
ミドリ十字中央研究所
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山内 紘一
ミドリ十字中央研究所
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荒川 良夫
Central Research Laboratories The Green Cross Corporation
-
横山 和正
株式会社ミドリ十字 中央研究所
-
山内 紘一
Central Research Laboratories The Green Cross Corporation
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