Inhibitory Effect of Bis[2-(E-2-alkenoylamino)ethyl] Disulfides and 2-(E-Octenoylamino)ethyl Carbamoylmethyl Sulfides on Carrageenin-Induced Paw Edema in Rats(Biological,Chemical)
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概要
- 論文の詳細を見る
Two series of bis[2-(E-2-alkenoylamino)ethyl] disulfides (compds. I) and 2-(E-alkenoylamino)ethyl carbamoylmethyl sulfides (compds. II) were synthesized from 2-traps unsaturated fatty acids (C_<6:1>-C_<14:1>) and cystamine, and their effects on carrageenin-induced paw edema were studied. Several of compds. I and II showed significant anti-edema activity at a dose of 25 mg/kg, i.p. These derivatives were much more potent than the starting materials. The alkene chain length influenced the activity. The compounds (compds. I-3, I-8, II-3 and II-8) with C_<8:1> and C_<13:1> fatty acids showed the highest activity in both series. Compounds I-3 and II-3 with the C_<8:1> fatty acid were also effective when administered orally at a dose of 10mg/kg.
- 公益社団法人日本薬学会の論文
- 1987-11-25
著者
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横山 和正
Central Research Laboratory, Green Cross Corporation
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伊東 進
阪大・薬
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小浜 靖弘
Faculty of Pharmaceutical Sciences, Osaka University
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大村 孝男
ミドリ十字、中研
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横山 和正
ミドリ十字、中研
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辻川 和丈
阪大薬
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辻川 和丈
Faculty of Pharmaceutical Sciences, Osaka University
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三村 務
Faculty of Pharmaceutical Sciences, Osaka University
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伊東 進
Faculty of Pharmaceutical Sciences, Osaka University
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岩井 正和
Central Reserach Laboratories, The Green Cross Corporation
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中島 博志
Faculty of Pharmaceutical Sciences, Osaka University
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中島 博志
Faculty Of Pharmaceutical Sciences Osaka University
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大村 孝男
ミドリ十字中央研究所
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大村 孝男
ミドリ十字・中研
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三村 務
大阪大学薬学部
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Tanaka K
Department Of Molecular Engineering Graduate School Of Engineering Kyoto University
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岩井 正和
Central Research Laboratories The Green Cross Corporation
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Tanaka Ken-ichiro
Faculty Of Pharmaceutical Sciences Okayama University
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大村 孝男
Central Research Laboratories, The Green Cross Corporation, Ltd.
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Itoh S
Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osada Univers
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Itoh S
Showa Denko Co. Tokyo Jpn
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横山 和正
Central Research Laboratories The Green Cross Corporation
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辻川 和丈
Faculty of Pharmaceutical Sciences, Okayama University
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