Effect of Various C_<16> Fatty Acids, Isopentadecanoic and Isomargaric Acids, on Stabilization of Rat Erythrocytes and Carrageenin-induced Edema
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概要
- 論文の詳細を見る
Several fatty acids, including 2-hexyldecanoic acid, iso-C_<15 : 0>, iso-C_<16 : 0>, and iso-C_<17 : 0> as branched series and various types of C_<16> fatty acids, were examined for protection of erythrocytes from heat-induced or hypotonic hemolysis, of heat-induced denaturation of bovine serum albumin (BSA) in vitro, and for inhibition of carrageenin-induced edema in hind paw of a rat in vivo. All of fatty acids tested were found to have a protective effect on heat-induced hemolysis of rat erythrocytes and heat-induced denaturation of BSA. Inhibitory effect on hypotonic hemolysis was recognized in all fatty acids except 2-hexyldecanoic acid, and iso-series especially showed greater activity. In regard to carrageenin-induced paw edema, only iso-C_<15 : 0> and iso-C_<16 : 0> exhibited inhibitory an effect, and other fatty acids had no effect.
- 公益社団法人日本薬学会の論文
- 1978-04-25
著者
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青沼 繁
Faculty of Pharmaceutical Sciences of Kinki University
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三村 務
Faculty of Pharmaceutical Sciences, Osaka University
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三村 務
大阪大学薬学部
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青沼 繁
Faculty Of Pharmaceutical Sciences Osaka University
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辻坊 裕
Faculty Of Pharmaceutical Science Osaka University
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大西 昇
Faculty of Pharmaceutical Sciences, Osaka University
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大西 昇
Faculty Of Pharmaceutical Sciences Osaka University
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増本 峰子
Faculty of Pharmaceutical Sciences, Osaka University
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増本 峰子
Faculty Of Pharmaceutical Sciences Osaka University
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