Serum Hepatocyte Growth Factor Activity and Hepatocyte Proliferation in Long-Evans with a Cinnamon-Like Coat Color Rats with Hepatic Lesions
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概要
- 論文の詳細を見る
We classified hepatic lesions spontaneously developed by Long-Evans with a cinnamon-like coat color (LEC) rats into the following four stages : Normal liver, acute hepatitis, chronic hepatitis, and hepatoma, by biochemical tests of the sera, and anatomical and histopathological examination of the livers. Hepatocyte growth factor (HGF) activity in the sera of LEC rats which developed acute hepatitis, chronic hepatitis, and hepatoma was higher than that of normal LEC rats. In paticular, HGF activity in the sera of the LEC rats with acute hepatitis was about 70-fold that of normal LEC rats. However, primary cultured hepatocytes of LEC rats with hepatic lesions were hardly proliferated by stimulation with EGF and insulin in vitro or with increased HGF in vivo. These results suggest that the hepatocytes of LEC rats with hepatic lesions disorder the signal transduction of growth factors.
- 社団法人日本薬学会の論文
- 1994-04-15
著者
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鈴木 信孝
Faculty Of Pharmaceutical Sciences Osaka University
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小濱 靖弘
大阪大学 薬 微薬品化
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辻川 和丈
阪大薬
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小濱 靖弘
Faculty of Pharmaceutical Sciences, Osaka University
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辻川 和丈
Faculty of Pharmaceutical Sciences, Osaka University
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三村 務
Faculty of Pharmaceutical Sciences, Osaka University
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田中 啓詞
Faculty of Pharmaceutical Sciences, Osaka University
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島岡 俊雄
Faculty of Pharmaceutical Sciences, Osaka University
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木村 正己
Department of Molecular Biology, Keio University School of Medicine
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杉山 俊博
First Department of Biochemistry, Akita University School of Medicine
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三村 務
大阪大学薬学部
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Tanaka K
Department Of Molecular Engineering Graduate School Of Engineering Kyoto University
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田中 啓詞
Faculty Of Pharmaceutical Sciences Osaka University
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小浜 靖弘
大阪大学薬学部
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Tanaka Ken-ichiro
Faculty Of Pharmaceutical Sciences Okayama University
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Mimura T
Osaka Univ. Osaka Jpn
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杉山 俊博
First Department Of Molecular Biology Akita University School Of Medicine
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木村 正己
Department Of Molecular Biology Keio University School Of Medicine
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木村 正己
Department Of Experimental Toxicology National Institute Of Industrial Health
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島岡 俊雄
Faculty Of Pharmaceutical Sciences Osaka University
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辻川 和丈
Faculty of Pharmaceutical Sciences, Okayama University
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