Inhibitory Effect of Bis[2-(E-2-octenoylamino)ethyl] Disulfide and 2-(E-Octenoylamino)ethyl Carbamoylmethyl Sulfide on Various Inflammation Models(Biological,Chemical)

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The anti-inflammatory action of bis[2-(E-2-octenoylamino)ethyl] disulfide (compd. I-3) and 2-(E-octenoylamino)ethyl carbamoylmethyl sulfide (compd. II-3) was evaluated in. various experimental inflammation models. By using the xylene ear method in mice, the bradykinin-induced capillary permeability test in rat skin and the ultraviolet erythema method in guinea pigs, it was demonstrated that compd. I-3 had a significant inhibitory effect on the first phase of inflammation, but compd. II-3 did not. It was also shown that leucocyte emigration into the pouch fluid (the second phase), which accumulated after carboxymethyl cellulose injection in rats, was suppressed by the administration of both compounds. Moreover, granuloma formation (the third phase) generated by the felt pellet or croton oil method in rats was reduced by both compds. I-3 and II-3. Successive administrations of compd. II-3 caused hypertrophy of the spleen and thymus and atrophy of the kidney, but similar administrations of compd. I-3 did not.
公益社団法人日本薬学会の論文
1987-11-25