Studies on Thermophile Products. IX. Isofatty Acid-Containing Phosphatidylglycerol That Enhances the Induction of Concanavalin A-Activated Suppressor T Cells
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概要
- 論文の詳細を見る
A new enhancer of the induction of concanavalin A (Con A)-activated suppressor T (Ts) cells has been demonstrated in the ethanolysate of Bacillus stearothermophilus UBT8038. It was purified by successive silica gel column chromatographies and identified as phosphatidylglycerol with C_<14 : 0>-C_<18 : 0> isofatty acids (Fr. 7-C). Mouse splenocytes activated with Con A and Fr. 7-C (0.01-1μg/ml) in vitro significantly suppressed the proliferative response of syngenic splenocytes by mitogen stimulation in a dose-dependent manner, compared to those stimulated by Con A alone. The immunosuppressive response enhanced by Fr. 7-C disappeared when the cell populations of Thy-1.2 or CD8 positive lymphocytes were depleted. The result strongly suggests that Fr. 7-C is an immunosuppressive substance which enhances the induction of Con A-activated CD8 positive Ts cells.
- 社団法人日本薬学会の論文
- 1994-09-15
著者
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伊東 進
阪大・薬
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小濱 靖弘
阪大薬
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小濱 靖弘
大阪大学 薬 微薬品化
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小濱 靖弘
Faculty of Pharmaceutical Sciences, Osaka University
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刀根 秀樹
Faculty of Pharmaceutical Sciences, Osaka University
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高江 慎一
Faculty of Pharmaceutical Sciences, Osaka University
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三村 務
Faculty of Pharmaceutical Sciences, Osaka University
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田中 啓詞
Faculty of Pharmaceutical Sciences, Osaka University
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田中 忍
Faculty of Pharmaceutical Sciences, Osaka University
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仙波 太郎
Faculty of Pharmaceutical Sciences, Osaka University
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伊東 進
Faculty of Pharmaceutical Sciences, Osaka University
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三村 務
大阪大学薬学部
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田中 啓詞
Faculty Of Pharmaceutical Sciences Osaka University
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小浜 靖弘
大阪大学薬学部
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Mimura T
Osaka Univ. Osaka Jpn
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仙波 太郎
Faculty Of Pharmaceutical Sciences Osaka University
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高江 慎一
Faculty Of Pharmaceutical Sciences Osaka University
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Itoh S
Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osada Univers
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刀根 秀樹
Faculty Of Pharmaceutical Sciences Osaka University
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Itoh S
Showa Denko Co. Tokyo Jpn
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