1-^<14>C-Palmitic Acidと1-^<14>C-Myristic Acidの正常およびGranuloma Pouchラットにおける生体内分布

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Comparative examinations were made on palmitic acid, which has an anti-inflammatory effect, and myristic acid, which has no such effect, for their incorporation into various tissues and body fluids in intact and granuloma pouch rats by oral administration of ^<14>C-labeled fatty acids. In intact rats, significantly higher radioactivity was found in the heart, liver, spleen, and adrenals 2 hr after administration of 1-^<14>C-palmitic acid, compared to that in the group given 1-^<14>C-myristic acid. This trend continued for 24 hr. In granuloma pouch-bearing rats, radioactivity showed a significantly higher distribution in the adrenals and pouch exudate 2 hr after ^<14>C-palmitic acid administration, compared to the group given myristic acid. This tendency continued for 24 hr. However, radioactivity in the pouch wall showed higher distribution in the rats given ^<14>C-myristic acid.
公益社団法人日本薬学会の論文
1978-05-25