Studies on Biological Activities of Melanin from Marine Animals. III. Inhibitory Effect of SM II (Low Molecular Weight Melanoprotein from Squid) on Phenylbutazone-Induced Ulceration in Gastric Mucosa in Rats, and Its Mechanism of Action
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概要
- 論文の詳細を見る
A low molecular weight melanoprotein from Ommastrephes bartrami LESUEL (Fr. SM II) has been reported to have a gastric secretion inhibitory activity in rats. The effect of Fr. SM II on the gastric mucosal defensive capability was studied in this investigation. It was demonstrated that Fr. SM II : i) counteracted ulceration induced by phenylbutazone and aspirin; ii) increased the contents of gastric glycoproteins in the ulcerated stomach; iii) lowered the activities of glycoprotein-degrading enzymes; and iv) increased the ^<35>SO^<2->_4 uptake into the gastric mucosa in intact rats concomitantly with an increase of glycoprotein content. It is suggested that the anti-ulcerogenic activity of Fr. SM II is based on its glycoprotein-increasing activity in the gastric mucosa.
- 公益社団法人日本薬学会の論文
- 1985-05-25
著者
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小田 泰雄
近畿大学薬学部
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小田 泰雄
Faculty of Pharmaceutical Sciences, Kinki University, Kowakae
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青沼 繁
Faculty of Pharmaceutical Sciences of Kinki University
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小田 泰雄
Faculty Of Pharmaceutical Sciences Kinki University Kowakae
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三村 務
Faculty of Pharmaceutical Sciences, Osaka University
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三村 務
大阪大学薬学部
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青沼 繁
Faculty Of Pharmaceutical Sciences Osaka University
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前田 和宏
Faculty Of Pharmaceutical Sciences Osaka University
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寺田 多一郎
Faculty of Pharmaceutical Sciences, Osaka University
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森下 佳苗
Faculty of Pharmaceutical Sciences, Osaka University
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森下 佳苗
Faculty Of Pharmaceutical Sciences Osaka University
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寺田 多一郎
Faculty Of Pharmaceutical Sciences Osaka University
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