Studies on Biological Activities of Melanin from Marine Animals. II. Purification of Melanin from Octopus vulgaris CUVIER and Its Inhibitory Activity on Gastric Juice Secretion in Rats
スポンサーリンク
概要
- 論文の詳細を見る
Octopus melanin obtained from ink bags of Octopus vulgaris CUVIER was found to inhibit gastric secretion in rats in the same way as that from Ommastrephes bartrami LESUEL. The molecular weight of this melanin fraction (which has an indole skeleton) was estimated to be over 200000 by gel filtration on Sephadex G-200,and the Octopus melanin fraction (Fr. OM) released several kinds of proteins in the presence of SDS. The chemical composition of Fr. OM was melanin pigment 79%, protein 17.5% and sugar 1.7%, so Fr. OM was considered to be a melanoprotein. Fr. OM significantly reduced gastric secretion in rats at the dose of 1 mg/kg, i.p., and also prevented both ulcer formation in pylorusligated rats and aspirin-induced ulcer.
- 社団法人日本薬学会の論文
- 1982-04-25
著者
-
三村 務
Faculty of Pharmaceutical Sciences, Osaka University
-
三村 務
大阪大学薬学部
-
前田 和宏
Faculty Of Pharmaceutical Sciences Osaka University
-
辻坊 裕
Faculty Of Pharmaceutical Science Osaka University
-
佐竹 幹雄
日本水産
-
佐竹 幹雄
The Central Research Laboratory of Nippon Suisan Co., Ltd.
-
藤田 孝夫
The Central Research Laboratory of Nippon Suisan Co., Ltd.
-
藤田 孝夫
The Central Research Laboratory of Nippon Suisan Co.
関連論文
- Structure-Activity Relationship Study of TXA_2 Receptor Antagonists. 4-[2-(4-Substituted Phenylsulfonylamino)ethylthio]phenoxyacetic Acids and Related Compounds
- Synthesis and Evaluation of Novel Thiazolidine Derivatives as Thromboxane A_2 Receptor Antagonists
- Pharmacological Activity of Chemically Modified Subfragment from Human Serum IgG. XIV. Inhibitory Effect of Carboxamide-Methylated Light Chain (G_1L) on Tyrosine Phosphorylation and Tumor Necrosis Factor-α Production from Murine Macrophages Stimulated by
- Induction of Unresponsiveness of Antigen-Specific T Lymphocytes by Oral Administration of Cedar Pollen Extract in Mice
- Studies on Thermophile Products. XI. Biological Effect of Antigen Presenting Inhibitor, Isofatty Acid-Containing Phosphatidylethanolamine, on Mouse Macrophages
- Studies on Thermophile Products. X. Further Biological Properties of Isofatty Acid-Containing Phosphatidylglycerol That Enhances the Induction of Suppressor T Cells
- Studies on Thermophile Products. IX. Isofatty Acid-Containing Phosphatidylglycerol That Enhances the Induction of Concanavalin A-Activated Suppressor T Cells
- Studies on Thermophile Products. VIII. Isolation of Bacillus stearothermophilus UBT8038,a Component That Inhibits Antigen Presentation on Mouse Macrophages
- Inhibitory Effect of Tuna Peptide on Endothelin Production in Cultured Endothelial Cells
- Studies on Thermophile Products. VII. Effect of 1,3-Di-14-methylpentadecanoyl Glycerol and Its Related Isofatty Acids on T Cell Proliferation in Vitro