ラット赤血球膜安定化およびカラゲニン浮腫に対する脂肪酸類の影響

概要

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Anti-inflammatory effect of C_<10>-C_<20> saturated fatty acids was examined by using heat-induced hemolysis, hypotonic hemolysis, heat-induced denaturation of bovine serum albumin (BSA), and carrageenin-induced paw edema as the experimental systems. 1) Several fatty acids, including C_<13 : 0> to C_<17 : 0>, were found to protect erythrocytes from heat-induced hemolysis, and C_<12 : 0> to C_<16 : 0> significantly inhibited hypotonic hemolysis in vitro. 2) All fatty acids tested showed a significant effect on heat-induced denaturation of BSA at a concentration of 5.0 μg/ml in vitro, but C_<16 : 0> methyl ester did not show any inhibitory effect at the same concentration. 3) Palmitic acid, its methyl ester, and oleic acid suppressed carrageenin-induced paw edema in rats by oral administration at the dosage of 200 mg/kg, but C_<16 : 0> methyl ester did not suppress it by intraperitoneal injection. 4) In adrenalectomized rats, palmitic acid also suppressed carrageenin-induced paw edema. 5) Palmitic acid inhibited the granuloma formation caused by felt-pellet at the dose of 100 mg/kg/day (oral) for 5 days, but did not show a significant effect on either exudation into the granuloma pouch or on formation of pouch wall.
公益社団法人日本薬学会の論文
1977-11-25