Bacillus属細菌の産生する生理活性物質の研究(第4報) : B.subtilis Kの培養濾液から得られるガマ心臓機能促進成分について
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概要
- 論文の詳細を見る
A substance promoting the function of toad heart was obtained as an isoelectric precipitate by adjusting pH of the culture filtrate of Bacillus subtilis K to 3.0. The precipitate was purified by chromatography on DEAE-cellulose column and then gel chromatography on Sephadex G-75. The substance was finally isolated by column chromatography over acid alumina. It seemed to be homogeneous by electrophoresis on polyacrylamide gel disc. This substance was found to be a lipoprotein which was derived from the cytoplasmic membrane fraction of the vegetative cells according to immunological examination. This substance increased the ^<32>P-uptake into chick myocardium 2 hr after intraperitoneal injection of 0.5 mg/chick.
- 公益社団法人日本薬学会の論文
- 1972-05-25
著者
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青沼 繁
大阪大学薬学部
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久岡 正史
大阪大学薬学部
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三村 務
大阪大学薬学部
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青沼 繁
Faculty Of Pharmaceutical Sciences Osaka University
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大谷 正洋
大阪大学薬学部
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近藤 覚
大阪大学薬学部
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