A Cytolytic Substance, Monopodialysin obtained from a Streptomyces. I. Isolation and Characterization of Monopodialysin produced by Streptomyces aureomonopodiales

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A intracellular cytolytic substance, named monopodialysin was isolated from the mycelium of a Streptomyces strain designated as Streptomyces aureomonopodiales. The cytolytic substance was purified by extraction with acetone, followed by column chromatography on silica gel and gel filtration on a column of Sephadex LH-20. Monopodialysin was obtained as colorless plate (M. W. <1000) and contained C, H, and O as elements. It showed very high hemolytic activity for several kinds of mammalian erythrocytes and its activity was inhibited by soy bean lecithin or cholesterol but no sucrose. Protoplasts of Bacillus subtilis and lysosomes from ratliver were also lysed but monopodialysin displayed no antimicrobial activity.
公益社団法人日本薬学会の論文
1978-03-25