Identification and Biological Activity of Fatty Acids as a Gastric Secretion Inhibitory Principle from Dried Brewer's Yeast
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概要
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An active principle having gastric juice secretion-inhibiting activity in pylorus-ligated rats was purified from the ethanol extract of dried brewer's yeast by column chromatography, preparative thin-layer chromatography on silica gel, and gel filtration on a Sephadex LH-20. The active principle was a fatty acid mixture, consisting of C_<10 : 0>, C_<12 : 0>, C_<14 : 0>, C_<15 : 0>, C_<16 : 0>, C_<16 : 1> (palmitoleic acid), C_<18 : 0>, C_<18 : 1> (oleic acid), and C_<18 : 2> (linoleic acid) as determined by gas chromatography-mass spectrometry of the methyl esters. The biological activity of each identified fatty acid on gastric juice secretion was assayed in pylorus-ligated rats at a dose of 100 mg/kg (i. p.); the C_<10 : 0>, C_<12 : 0>, C_<14 : 0>, C_<15 : 0>, and C_<16 : 0> acids markedly decreased gastric juice volume, total acid output, and total peptic activity. Gastric volume and total acid output were significantly inhibited by C_<16 : 1> acid, and the gastric volume was inhibited by C_<18 : 2> acid. Among the C_<10 : 0>, C_<12 : 0>, C_<14 : 0>, C_<15 : 0>, and C_<16 : 0> acids, the C_<12 : 0> and C_<14 : 0> acids significantly prevented ulcer formation in pylorus-ligated rats.
- 公益社団法人日本薬学会の論文
- 1980-04-25
著者
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武藤 徳男
大阪大学薬学部
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武藤 徳男
Faculty of Pharmaceutical Sciences, Osaka University
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青沼 繁
Faculty of Pharmaceutical Sciences of Kinki University
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三村 務
Faculty of Pharmaceutical Sciences, Osaka University
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三村 務
大阪大学薬学部
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青沼 繁
Faculty Of Pharmaceutical Sciences Osaka University
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辻坊 裕
Faculty Of Pharmaceutical Science Osaka University
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大塚 智美
Faculty of Pharmaceutical Sciences, Osaka University
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大塚 智美
Faculty Of Pharmaceutical Sciences Osaka University
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武藤 徳男
県立広島大学生命環境学部・院生命システム科学
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