Pharmacological Activity of Chemically Modified Subfragment from Human Serum IgG. XIV. Inhibitory Effect of Carboxamide-Methylated Light Chain (G_1L) on Tyrosine Phosphorylation and Tumor Necrosis Factor-α Production from Murine Macrophages Stimulated by
スポンサーリンク
概要
- 論文の詳細を見る
Carboxamide-methylated light chain (G_1L) from human serum IgG inhibited the secretion of tumor necrosis factor (TNF-α), one of the inflammatory cytokines, from adherent splenocytes and thioglycolate-induced peritoneal macrophages. The inhibition of TNF-α secretion by G_1L was associated with disappearance of tyrosine phosphorylation on about 40kDa protein when thioglycolate-induced peritoneal macrophages were stimulated with lipopolysaccharide (LPS). It is possible that this G_1L anti-inflammatory activity occurs through the blockage of the phosphorylation of about 40kDa protein.
- 社団法人日本薬学会の論文
- 1995-10-15
著者
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伊東 進
阪大・薬
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小濱 靖弘
阪大薬
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小濱 靖弘
大阪大学 薬 微薬品化
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辻川 和丈
阪大薬
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三村 務
Division of Bio-Medical and Immunological Chemistry, Faculty of Pharmaceutical Sciences, Osaka Unive
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竹内 勝義
Division of Bio-Medical and Immunological Chemistry, Faculty of Pharmaceutical Sciences, Osaka Unive
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平松 恵子
Division of Bio-Medical and Immunological Chemistry, Faculty of Pharmaceutical Sciences, Osaka Unive
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辻川 和丈
Division of Bio-Medical and Immunological Chemistry, Faculty of Pharmaceutical Sciences, Osaka Unive
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小濱 靖弘
Division of Bio-Medical and Immunological Chemistry, Faculty of Pharmaceutical Sciences, Osaka Unive
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伊東 進
Division of Bio-Medical and Immunological Chemistry, Faculty of Pharmaceutical Sciences, Osaka Unive
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三村 務
大阪大学薬学部
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Tanaka K
Department Of Molecular Engineering Graduate School Of Engineering Kyoto University
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小浜 靖弘
大阪大学薬学部
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Tanaka Ken-ichiro
Faculty Of Pharmaceutical Sciences Okayama University
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Mimura T
Osaka Univ. Osaka Jpn
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平松 恵子
Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osaka Univers
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Itoh S
Showa Denko Co. Tokyo Jpn
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竹内 勝義
Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osaka Univers
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