カルノシンおよびアンゼリンに関連するβ-Alanyl-peptidesの生理化学的検討

概要

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As a part of studies on the inhibitory effect of anserine and carnosine on cardiac movement, some β-alanyl-peptides were synthesized, and the physiological action of these peptides was compared with that of anserine and carnosine. β-Alanyl-L-glutamic acid showed following results : This peptide inhibited the movement of isolated heart of toads and rats, antagonized oxytocin in isolated rat uterus, contracted isolated small intestine of guinea pigs, and increased the mitochondrial oxidative phosphorylation of rat myocardium and incorporation of ^<32>P into chick myocardium. Toxicity of this peptide was weak (3.36 g/kg). Distribution of ^3H-β-alanyl-L-glutamic acid in rat organs was examined and it was found that the incorporation of radioactivity was higher in the prostate, seminal vesicle, and kidney, and lower in testis and in large and small intestines. The radioactivity from ^3H-β-alanyl-L-glutamic acid in urine accounted for about 3/5 of the total radioactivity.
公益社団法人日本薬学会の論文
1970-02-25