Fate of Perfluorochemicals in Animals after Intravenous Injection or Hemodilution with Their Emulsions

概要

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The tissue distribution and excretion of perfluorochemicals (PFCs) in the mixed PFC emulsion, which were a mixture of 7 parts Perfluorodecalin (FDC) and 3 parts Perfluoro-tripropylamine (FTPA), were studied in rats and dogs hemodiluted to a hematocrit of 5% and monkeys to 1%. The half life of both PFCs in rats given 4g/kg body weight were calculated from their expiratory excretion rate to be about 7 days for FDC and 63 days for FTPA. Both PFCs in the mixed PFC emulsion were excreted according to respective excretion rate, indicating no mutual effect of combined use on respective excretion rate. Both PFCs were taken up into the liver, spleen and bone marrow in the majority and eliminated through expiration as the main route and bile as the minor route, the maximum deposition occurring in 4 days after infusion. FDC localized in the tissues was rapidly eliminated and no longer detected both in dogs at 6 months after hemodilution and in monkeys at 4 months. On the other hand, FTPA was also fairly rapidly eliminated from the tissues, but at a slower rate and it was retained only in the liver and spleen in both of dogs at 6 months and monkeys at 4 months in a very small amount. The absence of excess fluoride ion in urine and the coincidence of mass spectra of FDC and FTPA retained in the liver with those of the standard suggested that both of them were not catabolized in vivo.
公益社団法人日本薬学会の論文
1978-03-25