Role of Oncotic Agents in Saving Effect of Perflurochemical Emulsions in Hemodilution

スポンサーリンク

概要

• 論文の詳細を見る

• Survival prolongation was studied in rats which were hemodiluted to a hematocrit value of as low as 7,4,or 1% by stepwise exchange transfusion, alternating bleeding through the artery and infusing a perfluorochemical (FC) emulsion into the vein, with the combined use of oncotic agents taken into consideration to maintain the circulating plasma volume, and the following results were found : (1) Plasma expander (PE) was indispensable to the use of FC emulsion for the survival of exchange-transfused rats. As an oncotic agent to be combined with FC emulsion, homologous plasma and 6% hydroxyethyl-starch (HES) solution were better than dextran in rats. (2) At the exchange transfusion with FC emulsion+PE, totaling 1.2 times the volume of blood eliminated, survival effect was better at a ratio of FC emulsion to PE of 1 : 3 than 3 : 1. (3) Supplementary infusions of Fluosol-DA (an improved FC emulsion made isooncotic with 2.7% HES) carried out after the exchange transfusion at intervals of 24 hr were effective in prolongation of survival.

• 公益社団法人日本薬学会の論文
• 1977-09-25

著者

• 松本 剛

  Central Research Laboratories The Green Cross Corporation (midorijuji)

• 須山 忠和

  Central Research Laboratories The Green Cross Corporation (midorijuji)

• 渡辺 正弘

  Central Reserach Laboratories, The Green Cross Corporation

• 花田 秀一

  Central Research Laboratories Green Cross Corporation

• 浜野 哲夫

  Central Research Laboratories, The Green Cross Corporation (Midorijuji)

• 内藤 良一

  Central Research Laboratories, The Green Cross Corporation (Midorijuji)

• 浜野 哲夫

  Central Research Laboratories The Green Cross Corporation (midorijuji)

• 内藤 良一

  Central Research Laboratories The Green Cross Corporation (midorijuji)

関連論文

• 53. プロトポルフィリンの抗炎症・抗アレルギー作用(第14回日本アレルギー学会総会)
• Further Studies on the Anti-ulcerogenic Effects of Compound, 2-(E-2-Decenoylamino)ethyl 2-(Cyclohexylethyl) SUlfide
• Effects of 2-(E-2-Decenoylamino)ethyl 2-(Cyclohexylethyl) Sulfide on Varioius Ulcer Models in Rats
• Role of Oncotic Agents in Saving Effect of Perflurochemical Emulsions in Hemodilution
• 2. 実験喘息および線溶活性におよぼすプロトポルフィリンの影響(V プラスミンとアレルギー)(第16回日本アレルギー学会総会)
• プロトポルフィリンの抗炎症作用[IV] -経口投与せるプロトポルフィリンの実験的肝硬変およびアナフィラキシー・ショックに対する効果-
• プロトポルフイリンの生物活性 : 実験喘息および in vitro アナフィラキシーに及ぼす影響
• プロトポルフィリンの抗炎症作用 [III] -馬杉腎炎におよぼす影響-
• プロトポルフィリンの抗炎症作用 [II] -アレルギー反応・抗体産生・免疫溶血反応におよぼす影響-
• プロトポルフィリンの抗炎症作用(I) 実験的肝硬変・肉芽腫・発痘におよぼす影響
• Preparation and Biological Activity of 2-[4-(Thiazol-2-yl)phenyl]propionic Acid Derivatives Inhibiting Cyclooxygenase
• Inhibitory Effect of 2-(E-2-Alkenoylamino)ethyl Alkyl sulfides on Gastric Ulceration in Rats. II. Structure and Activity Relationships of 2-(E-n or Z-n-Decenoylamino)ethyl Alkyl Sulfides
• Effect of N-3-(4-Hydroxyphenyl)propionyl Pro-Pro-Gly-Ala-Gly on Calcium-Induced Arrhythmias
• Determination of Particle Size Distribution of Fluorocarbon Emulsion by Means of Centrifugal Sedimentation : A Proposal for Specifying the Particle Size Distribution

もっと見る 閉じる

スポンサーリンク