プロトポルフイリンの生物活性 : 実験喘息および in vitro アナフィラキシーに及ぼす影響

概要

論文の詳細を見る
The action of protoporphyrin on experimental asthma induced in guinea pigs was investigated. The result obtained from the observation of the asthmatic sign and of the chest movement on stethograph indicated that protoporphyrin exerted a marked preventive effect on allergic asthma induced in sensitized guinea pigs, and on acetylcholine asthma induced by inhalation of acetylcholine aerosol. However, histamine asthma induced by histamine inhalation was not prevented by protoporphyrin administration. While, in vitro anaphylactic release of histamine from guinea pig lung was significantly reduced by the prechallenge administration of protoporphyrin. These data suggest that preventive effects of protoporphyrin on asthmatic attack would be partly due to suppression of the release of bronchoconstrictor such as histamine from the anaphylactic tissue. Prednisolone also showed preventive effect on allergic asthma in guinea pig, but not on asthmatic attack provocated by acetylcholine or histamine inhalation.
日本アレルギー学会の論文
1966-07-30