PARACELLULAR CHANNEL CHARACTERIZED BY NON-ELECTROLYTE PERMEATION THROUGH THE COLONIC MEMBRANE OF THE RAT
スポンサーリンク
概要
- 論文の詳細を見る
The mucosa-to-serosa permeability of non-electrolytes through the stripped colonic rat mucosa was examined in a Ussing-type chamber. The permeation clearances for inulin (12-15 Å radius) to erythritol (3.2 Å radius) increased linearly with the increase in their free diffusion coefficients. On the other hand, the clearances of glycerol, thiourea and urea of less than 3 Å radius increased in excess of what would be expected considering the above linearity. This suggests that there are large pores that do not restrict diffusive flow and small pores of 3 Å radius or greater that restrict diffusion in the paracellular channel. The transcellular permeation also occurred in a tracer efflux experiment with urea preloaded in colonic stripped mucosa. It was not ruled out that the higher permeability of the nonelectolytes less than 3 Å in radius was due to a transcellular route in parallel with the paracellular one.
- 公益社団法人日本薬学会の論文
著者
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HAYASHI Masahiro
Department of Dermatology, Yamagata University School of Medicine
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TOMITA Mikio
Department of Biopharmaceutics, Tokyo College of Pharmacy
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AWAZU Shoji
Department of Biopharmaceutics, School of Pharmacy, Tokyo University of Pharmacy and Life Science
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Tomita M
Department Of Drug Absorption And Pharmacokinetics School Of Pharmacy Tokyo University Of Pharmacy A
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AWAZU Shoji
東京薬科大学薬学部 薬物動態制御学教室
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SAWADA Toyohiro
Department of Biopharmaceutics, Tokyo College of Pharmacy
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Tomita Mikio
Department Of Biopharmaceutics School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Tomita Mikio
Department Of Biopharmaceutics Tokyo College Of Pharmacy
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Tomita Mikio
Department Of Drug Absorption And Pharmacokinetics School Of Pharmacy Tokyo University Of Pharmacy A
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Sawada Toyohiro
Department Of Biopharmaceutics Tokyo College Of Pharmacy
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Awazu Shoji
Deparment Of Biopharmaceutics Tokyo College Of Pharmacy
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Hayashi Masahiro
Department Of Biological Production And Enviromental Science Faculty Of Agriculture The University O
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Awazu S
Department Of Biopharmaceutics School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Hayashi Masahiro
Department of Absorption and Pharmacokinetics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
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