HETEROGENEOUS DISTRIBUTION OF CONJUGATION ACTIVITIES OF HARMOL IN ISOLATED RAT LIVER CELLS
スポンサーリンク
概要
- 論文の詳細を見る
The regional distribution of the conjugation reaction activities of harmol was examined in isolated rat liver cells fractionated to the centrilobular and periportal regions. The heterogeneous distribution in the conjugation rates per unit cell numbers was found only in glucuronidation. The difference in the metabolic intrinsic clearance per total cell numbers in each region was mainly due to the cell numbers, resulting that the metabolic abilities in both reactions are higher in the periportal region than the centrilobular region. This finding in sulfate conjugation is consistent with the results in the isolated perfused liver previously presented by other investigators but the result that in glucuronide conjugation is contradictory to them.
- 公益社団法人日本薬学会の論文
著者
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HAYASHI Masahiro
Department of Dermatology, Yamagata University School of Medicine
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AWAZU Shoji
Department of Biopharmaceutics, School of Pharmacy, Tokyo University of Pharmacy and Life Science
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MIZUMA Takashi
Department of Biopharmaceutics, Tokyo College of Pharmacy
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Araya Hiroshi
Department of Chemistry, Tokyo Institute of Technology
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HORIE Toshiharu
Departments of Biopharmaceutice, Graduate School of Pharmaceutical Sciences, Chiba University
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AWAZU Shoji
東京薬科大学薬学部 薬物動態制御学教室
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Araya Hiroshi
Department Of Biopharmaceutics Tokyo College Of Pharmacy
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Mizuma Takashi
Department Of Biopharmaceutics Tokyo College Of Pharmacy
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Mizuma Takashi
Department Of Biopharmaceutics And Drug Rational Research Center School Of Pharmacy Tokyo University
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Awazu Shoji
Deparment Of Biopharmaceutics Tokyo College Of Pharmacy
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Awazu S
Department Of Biopharmaceutics Tokyo College Of Pharmacy:department Of Pharmaceutics Research Center
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Hayashi Masahiro
Department Of Biological Production And Enviromental Science Faculty Of Agriculture The University O
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澤山 茂
東京農大 栄養
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Horie Toshiharu
Department Of Biopharmaceutics Graduate School Of Pharmaceutical Sciences Chiba University
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Awazu S
Department Of Biopharmaceutics School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Mizuma Takashi
Department of Applied Chemistry, Faculty of Engineering, Osaka University
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