Preference of Peyer's Patches to Jejunal Epithelium for Intestinal Absorption of Oligopeptides, Tyrosylglycylglycine and D-Kyotorphin
スポンサーリンク
概要
- 論文の詳細を見る
The intestinal absorption of oligopeptides, peptidase-degradable tyrosylglycylglycine (TGG) and peptidase-resistant L-tyrosyl-D-arginine (D-kyotorphin, D-KTP) across Peyer's patches (PP) in rabbit intestine were studied using an Ussing-type chamber and in situ closed perfusion methods. The clearance for the serosal appearance of intact TGG across PP by the Ussing-type chamber method was a little higher than that across the jejunal epithelium (JE). Meanwhile, the in situ closed perfusion experiment showed that the clearance for the plasma appearance of intact TGG across PP was about 10 times that of JE. Furthermore, it was shown that the clearance for the plasma appearance of D-KTP in PP was about twice that in JE by the in situ closed perfusion method, indicating that the membrane permeability of PP was higher than that of JE. Therefore, these results indicate that PP had less metabolic peptidase activity than JE, and that the PP was a suitable site for the intestinal absorption of oligopeptides, especially peptidase-degradable peptides.
- 公益社団法人日本薬学会の論文
- 1997-09-15
著者
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AWAZU Shoji
Department of Biopharmaceutics, School of Pharmacy, Tokyo University of Pharmacy and Life Science
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MIZUMA Takashi
Department of Biopharmaceutics, Tokyo College of Pharmacy
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AWAZU Shoji
東京薬科大学薬学部 薬物動態制御学教室
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Awazu S
Tokyo Coll. Pharmacy Tokyo Jpn
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Awazu Shoji
Department Of Biopharmaceutics Tokyo College Of Pharmacy:department Of Pharmaceutics Research Center
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Mizuma Takashi
Department Of Biopharmaceutics Tokyo College Of Pharmacy
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Mizuma Takashi
Department Of Biopharmaceutics And Drug Rational Research Center School Of Pharmacy Tokyo University
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HASETO Shingo
Department of Biopharmaceutics, School of Pharmacy, Tokyo University of Pharmacy and Life Science
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OUCHI Hiroyuki
Department of Biopharmaceutics, School of Pharmacy, Tokyo University of Pharmacy and Life Science
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ISODA Tomonori
Department of Biopharmaceutics, School of Pharmacy, Tokyo University of Pharmacy and Life Science
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HAYASHI Masahiro
(Present address)Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Science University
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Awazu Shoji
Deparment Of Biopharmaceutics Tokyo College Of Pharmacy
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Haseto Shingo
Department Of Biopharmaceutics School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Isoda Tomonori
Department Of Biopharmaceutics School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Awazu S
Department Of Biopharmaceutics School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Mizuma Takashi
Department of Applied Chemistry, Faculty of Engineering, Osaka University
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