Unique heparan sulfate from shrimp heads exhibits a strong inhibitory effect on infections by dengue virus and Japanese encephalitis virus

スポンサーリンク

概要

• 論文の詳細を見る

• The structure and biological activities of a highly sulfated heparan sulfate (HS) extracted from shrimp (Penaeus brasiliensis) heads were characterized. Structurally the shrimp HS was more heterogenous than heparin, although it is still highly sulfated. The molecular mass of the shrimp HS preparation was determined to be 32.3 kDa by gel filtration HPLC. Analysis by surface plasmon resonance demonstrated that various growth/differentiation factors specifically bound to the shrimp HS with comparable affinity. Notably, the shrimp HS had a greater inhibitory effect against infections by dengue virus type 2 as well as Japanese encephalitis virus than heparin. Experiments on anticoagulant activity indicated that the shrimp HS exhibited significant anti-thrombin activity, but less than the commercial heparin. Hence, the HS preparation from shrimp heads, an industrial waste, is a prospective agent for a variety of clinical applications.

• 2011-08-19

著者

• 笠間 健嗣

  東京医科歯科大学分析機器室

• Sugahara Kazuyuki

  神戸薬科大学 生化

• Suzuki Y

  School Of Pharmaceutical Sciences University Of Shizuoka

• Takahashi Noriko

  Department Of Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences Core Research Fo

• Sugahara Kazuyuki

  Hokkaido Univ. Sapporo

• Hidari Kazuya

  Department Of Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences:core Research Fo

• Hidari Kazuya

  宮武内科

• Hidari Kazuya

  静岡県立大学 薬学部生体分子薬学分野

• Suzuki Y

  Fukuoka Inst. Technol. Fukuoka

• Hidari Kazuya

  Department Of Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences:core Research Fo

• Hidari Kazuya

  Department Of Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences

• 鈴木 陽子

  Meiji College Of Pharmacy

• Suzuki T

  Department Of Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences:core Research Fo

• Yamada Shuhei

  Department Of Biochemistry Kobe Pharmaceutical University

• Suzuki Y

  Department Of Pharmacobiology And Therapeutics Faculty Of Pharmacy Meijo University

• 笠間 健嗣

  東京医科歯科大・機器分析センター

• Kasama T

  Tokyo Medical And Dental Univ. Tokyo Jpn

• Kasama Takeshi

  Department Of Veterinary Science National Institute Of Infectious Diseases

• 笠間 健嗣

  第35回bmsコンファレンス実行

• Kasama Takeshi

  Instrumental Analysis Research Center For Life Science Tokyo Medical And Dental University

• Kasama Takeshi

  Tokyo Medical And Dental University

• Kasama Takeshi

  Laboratory For Biomedical Analysis Faculty Of Medicine Tokyo Medical And Dental University

• 笠間 健嗣

  東大医生化

• Suzuki Y

  Core Research For Evolutional Science And Technology (crest Jst) University Of Shizuoka School Of Ph

• 笠間 健嗣

  東医歯大

• Suzuki Y

  Grad. Sch. Bioagric. Sci. Nagoya Univ.

• Sugahara Kazuyuki

  Dept. Of Biochemistry. Kobe Pharmaceutical University

• Yamada S

  Department Of Bioscience And Biotechnology Fuculty Of Engineering Okayama University

• Suganuma Taiyo

  (pressent Address)department Of Pharmacology Tokyo Women's Medical University

• Suzuki Takashi

  Department Of Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences:core Research Fo

• Suzuki Y

  Department Of Pharmacology Faculty Of Pharmacy Meijo University

• Hidari Kazuya

  Univ. Shizuoka Shizuoka

関連論文

• Protective Effect of Prostaglandin EP_4-Receptor Agonist on Anti-glomerular Basement Membrane Antibody-Associated Nephritis
• コレステロール生合成障害を確認できたSmith-Lemli-Opitz症候群の1例
• Identification and Characterization of Carbohydrate Molecules in Mammalian Cells Recognized by Dengue Virus Type 2
• A Unique Phosphatidylinositol Bearing a Novel Branched-Chain Fatty Acid from Rhodococcus equi Binds to Influenza Virus Hemagglutinin and Inhibits the Infection of Cells
• lnhibitory action of sulfatide a putative ligand for L-selectiv on B cell proliferation and lg prodrction
• 塩基性糖脂質の質量分析 : ウシ脳の新規塩基性糖脂質 glyceroplasmalopsychosine で観測された分子内転位反応
• Recognition of N-Glycolylneuraminic Acid Linked to Galactose by the α2,3 Linkage Is Associated with Intestinal Replication of Influenza A Virus in Ducks
• The New Role of Disodium Cromoglycate in the Treatment of Adults with Bronchial Asthma
• In Vitro Inhibition of Human Influenza A Virus Infection by Fruit-Juice Concentrate of Japanese Plum (Prunus mume SIEB. et ZUCC)(Microbiology)
• Clarithromycin Inhibits Progeny Virus Production from Human Influenza Virus-Infected Host Cells(Microbiology)
• Suppression of the Biosynthesis of Cellular Sphingolipids Results in the Inhibition of the Maturation of Influenza Virus Particles in MDCK Cells(Highlighted paper selected by Editor-in-chief,Biochemistry)
• In Vitro and in Vivo Inhibitory Effects of Disodium Cromoglycate on Influenza Virus Infection(Pharmacology)
• Duck and Human Pandemic Influenza A Viruses Retain Sialidase Activity under Low pH Conditions^1
• A Macrocyclic Sialic Acid Cluster as a Host, as an Adsorbate, and as a Ligand for Lectin and Virus
• Ganglioside GM_ on the Cell Surface Is Involved in the Infection by Human Rotavirus KUN and MO Strains
• 血清ステロールのUV-HPLC分析 : 先天性ステロール代謝異常症の生化学診断
• Th1/Th2-Balancing Immunomodulating Activity of Gel-Forming(1→3)-β-Glucans from Fungi
• Adjuvant Effect of Grifolan on Antibody Production in Mice
• Effects of Development on Acetoacetyl-CoA Synthetase Biosynthesis in Rat Liver
• Involvement of chondroitin sulfate E in the liver tumor focal formation of murine osteosarcoma cells
• Functions of chondroitin sulfate/dermatan sulfate chains in brain development: Critical roles of E and iE disaccharide units recognized by a single chain antibody GD3G7.
• Effects of KD3-671, an Angiotensin II Type 1 Receptor Antagonist, on Anti-Thy-1 Nephritis in Rats
• Involvement of Prostaglandin E_2 in Clearance of Aggregated Protein via Protein Kinase A in Glomeruli
• Thromboxane A_2 Interferes with a Disposal Process of Aggregated Protein in Glomeruli
• Association study of the C3 gene with adult and childhood asthma
• ヒト骨髄中のホスホリパーゼA2
• Storage of Gangliosides GM2 and Fucosyl GM1 in the Kidney of MCC Strain of Mastomys (Praomys coucha)
• 聴神経腫瘍におけるガングリオシド
• 雄ウシ精子、生殖器および生殖腺液の糖脂質組成
• 脳転移に関連するガングリオシド
• High 8-dehydrocholesterol level in a typical case of Conradi-Hunermann-Happle syndrome with a novel H76Y missense mutation
• Target Proteins of the Cytosolic Thioredoxins in Arabidopsis thaliana
• INVOLVEMENT OF LPA IN BRANCHING MORPHOGENESIS OF FETAL MOUSE SUBMANDIBULAR GLAND(Developmental Biology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
• Unexpected Fragmentation of a Novel Cationic Glycosphingolipid, Glyceroplasmalopsychosine, by Electrospray Ionization and Low Energy Multistage Mass Spectrometry
• 「第35回BMSコンファレンス」開催報告
• GC/MSを用いた神経細胞のメタボローム的解析
• 海洋性細菌由来シアル酸転移酵素による有用ガングリオシド合成
• ペルオキシソーム病の生化学診断のためのLC/MSによるコレステロールエステルの分析
• HPLCによる血清ステロールの分析
• 微生物由来のシアル酸転移酵素による in vitro ガングリオシド合成
• 先天性ステロール代謝異常症のHPLCによる生化学診断法
• ガラクトシルセラミド発現因子-1 : 結合蛋白の検索と同定
• ホスファチジルグルコースは細胞で何をしているのか : 1価の組み換え Fab 抗体GL-7を使って
• 脂質研究における質量分析の歩みと装置の進歩
• マルチリアクティブなヒト単クローン抗i寒冷凝集素によって臍帯血球に見い出された新しいホスホグリセロリピド、ホスファチジルグルコース
• セラミド類似化合物によるアポトーシスの誘導
• 四重極型質量分析計
• Synthetic Studies on Selection Ligands/Inhibitors. Synthesis and Biological Evaluation of Sulfated and Phosphorylated β-D-Galacto- and Lactopyranosides Containing Fatty-Alkyl Residues of Different Carbon Chain Lengths
• Influenza A Virus-Binding Activity of Glycoglycerolipids of Aquatic Bacteria
• P-564 MULTI-DIMENSIONAL HPLC MAPPING METHOD FOR STRUCTURAL ANALYSES OF N-GLYCANS AND ITS APPLICATIONS TO N-GLYCOSYLATION PROFILING OF ORGANISMS AND TISSUES
• Insufficient Expression of Cyclooxygenase-2 Protein Is Associated With Retarded Degradation of Aggregated Protein in Diabetic Glomeruli
• Increase in the Deposition of Aggregated Protein in the Glomeruli of Spontaneously Diabetic Mice
• Sulfatide and Its Synthetic Analogues Recognition by Moraxella catarrhalis
• β-Thujaplicin Zinc Chelate Induces Apoptosis in Mouse High Metastatic Melanoma B16BL6 Cells
• Identification of human hyaluronidase-4 as a novel chondroitin sulfate hydrolase that preferentially cleaves the galactosaminidic linkage in the trisulfated tetrasaccharide sequence
• Isolation and characterization of a novel chondroitin sulfate from squid liver integument rich in N-acetylgalactosamine(4,6-disulfate) and glucuronate(3-sulfate) residues
• Role of Sialylglycoconjugate(s) in the Initial Phase of Metastasis of Liver-metastatic RAW117 Lymphoma Cells
• Association of the RIP2 Gene with Childhood Atopic Asthma
• Association between genetic variation in the gene for death-associated protein-3 (DAP3) and adult asthma
• Demonstration of the hepatocyte growth factor signaling pathway in the in vitro neuritogenic activity of chondroitin sulfate from ray fish cartilage
• Catalytic Action of Azolium Salts. IX. Synthesis of 6-Aroyl-9H-purines and Their Analogues by Nucleophilic Aroylation Catalyzed by Imidazolium or Benzimidazolium Salt
• Carbon-Carbon Bond Cleavage of α-Hydroxybenzylheteroarenes Catalyzed by Cyanide Ion : Retro-Benzoin Condensation Affords Ketones and Heteroarenes and Benzyl Migration Affords Benzylheteroarenes and Arenecarbaldehydes
• Carbon-Carbon Bond Cleavage of α-Substituted Benzoins by Retro-Benzoin Condensation : A New Method of Synthesizing Ketones
• Catalytic Action of Azolium Salts. VIII. Oxidative Aroylation with Arenecarbaldehydes Catalyzed by 1,3-Dimethylbenzimidazolium Iodide
• A New Method of Synthesizing Deoxybenzoins from 1,3-Dimethyl-2-(α-benzyloxybenzyl)imidazolium and 1,3-Dimethyl-2-(α-benzyloxybenzyl)benzimidazolium Iodides Based on Wittig-Type Rearrangement
• Olefin-Insertion Reaction between the Carbonyls of Benzils ; Formation of 1, 4-Diketons by Michael Addition Catalyzed by Cyanide Ion
• SYNTHESIS OF KETONES BY RETRO-BENZOIN CONDENSATION CATALYZED BY POTASSIUM CYANIDE
• Antiproteinuric Effect of KD3-671, an Angiotensin II Type 1 Receptor Antagonist, in Rats With Accelerated Passive Heymann Nephritis
• An association study of asthma and related phenotypes with polymorphisms in negative regulator molecules of the TLR signaling pathway
• Induction of Cyclooxygenase-2 Expression in Glomeruli by Aggregated Protein
• L-Tryptophan as an Antioxidant in Human Placenta Extract
• Antioxidant Properties of a New Type of Polyene, Falconensone A and Its Derivatives
• Induction of Apoptosis in the Human Promyelocytic Leukemia Cell Line HL60 by Falconensone A and Its Derivatives, New Polyenes
• Suppressive Effects of Uracil, Tyrosine, and Phenylalanine Contained in Human-Placenta Extract on Acute Ethanol-Induced Liver Injury in Mice
• Purification and Identification of Antioxidant Substances in Human-Placenta Extracts
• Z-335,a Thromboxane A_2 Receptor Antagonist, Suppresses the Progression of Arachidonic Acid-Induced Hind Limb Gangrene in Rats
• Arachidonic Acid-Induced Hind Limb gangrene : A New Experimental Rat Model of Paripheral Vascular Disease
• New Zinc (II) Complexes with Tetradentate Amino Acid Derivatives: Structure Characterization, Solution Chemistry, and in vitro Insulinomimetic Activity
• New Insulinomimetic Zinc(II)Complexes of α-Amino Acids and Their Derivatives with Zn(N_2O_2)Coordination Mode
• Association of Liposomes Containing a Soybean-Derived Sterlyglucoside Mixture with Rat Primary Cultured Hepatocytes
• Formation of Retinoyl-CoA in Rat Tissues
• Effects of SK-896, a New Human Motilin Analogue ([Leu^]motilin-Hse), on Postoperative Ileus in Dogs after Laparotomy
• Metabolic Fate of SK-896, a New Human Motilin Analogue ([Leu^]motilin-Hse) (III) : Feto-Placental Transfer and Excretion into Milk in Rats after Single Intravenous Injection of^3H-SK-896
• Metabolic Fate of SK-896, a New Human Motilin Analogue ([Leu^]motilin-Hse) (II) : Blood and Plasma Concentration and Excretion in Rats after Single Intravenous Injection or Constant Rate Intravenous Infusion of ^3H-SK-896
• Metabolic Fate of SK-896, a New Human Motilin Analogue ([Leu^]motilin-Hse) (I) : Distribution and Accumulation in Rats after Single or Repeated Intravenous Injection of ^3H-SK-896
• Anti-ulcer Effects of Antioxidants, Quercetin, a-Tocopherol, Nifedipine and Tetracycline in Rats
• 線虫 Caenorhabditis elegans におけるコンドロチン加水分解酵素
• 多硫酸化コンドロイチン硫酸の構造と機能 : 特有の硫酸化パターンと神経細胞機能調節活性
• Filaggrin null mutations are associated with atopic dermatitis and elevated levels of IgE in the Japanese population: a family and case–control study
• Biological Activity of p-Methylaminophenol, an Essential Structural Component of N-(4-Hydroxyphenyl)retinamide, Fenretinide
• Considerations for Accurate Whole Plant Photosynthesis Measurement
• C-reactive protein is associated with cigarette smoking-induced hyperfiltration and proteinuria in an apparently healthy population
• Antioxidant Properties of N-(4-Hydroxyphenyl)retinamide (Fenretinide)
• Unique heparan sulfate from shrimp heads exhibits a strong inhibitory effect on infections by dengue virus and Japanese encephalitis virus
• Characterization of Photosynthetic Glycogen and α-Glucosidase from Thermophilic Cyanobacteria, Lyngbya-Phormidium-Plectonema Group B
• Glycogen as Primordial Carbon Reserve and α-Glucosidase in the Genera Lyngbya-Phormidium-Plectonema, Thermophilic Cyanobacteria
• Analysis of the structure and neuritogenic activity of chondroitin sulfate/dermatan sulfate hybrid chains from porcine fetal membranes
• A small oxazine compound as an anti-tumor agent : A novel pyranoside mimetic that binds to VEGF, HB-EGF, and TNF-α
• Development of a mouse monoclonal antibody against the chondroitin sulfate-protein linkage region derived from shark cartilage
• Replication of genetic association studies in asthma and related phenotypes

もっと見る 閉じる

スポンサーリンク