Antioxidant Properties of a New Type of Polyene, Falconensone A and Its Derivatives
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概要
- 論文の詳細を見る
Falconesones A and B are new type of yellow compound extracted from ascomycetous fungi, Emericella falconensis. Falconensone A p-bromophenylhydrazone and falconensone A dioxime are derivatives of falconensone A which have also been synthesized recently. The structural similarity of the falconensones to α-tocopherol (vitamin E) led us to investigate whether falconensones exhibit antioxidant activity. These studies found that falconensone A p-bromophenylhydrazone and falconensone A dioxime scavenge α, α-diphenyl-β-picrylhydrazyl (DPPH) radical in a 1 : 1 ratio in contrast to vitamin E, where a 1 : 2 ratio relative to DPPH radicals was observed. In addition, linoleic acid peroxidation initiated by hydroxyl radicals was diminished by falconensone A p-bromophenylhydrazone to a greater extent than by vitamin E, and lipid peroxidation in rat liver microsome was reduced byfalconensone A dioxime and falconensone A p-bromophenylhydrazone. In contrast, falconensone A and falconensone B, the 4'-nor-methyl derivative of falconensone A, showed much lower activity or were inactive in scavenging radicals. These results suggest that falconensone A p-bromophenylhydrazone and falconensone A dioxime, may be useful new antioxidant agents, wherein the bromophenyl and hydroxy residues of falconensone A may be important for antioxidant activity. Based on these results, derivatives of falconensone A appear to be effective antioxidants that may have clinical utility for diseases treated with vitamin E.
- 公益社団法人日本薬学会の論文
- 2000-08-01
著者
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Takahashi Noriko
星薬科大学医薬品化学研究所 病態機能制御学研究室
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Takahashi N
Faculty Of Pharmaceutical Sciences Hoshi University
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Takahashi Noriko
Faculty Of Pharmaceutical Sciences Hoshi University
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Takahashi Noriko
Department Of Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences Core Research Fo
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Takahashi N
Laboratory Of Physiological Chemistry Institute Of Medicinal Chemistry Hoshi University
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FUKUI Tetsuya
Department of Health Chemistry, Hoshi University
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Kawai Ken-ichi
Department Of Health Chemistry Faculty Of Pharmaceutical Sciences Hoshi University
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Fukui T
Hoshi Univ. Tokyo Jpn
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Fukui T
Byotai‐seiri Lab. Tokyo Jpn
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Fukui Tetsuya
Department Of Health Chemistry
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TAMAGAWA Kayoko
Faculty of Pharmaceutical Sciences, Hoshi University
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TAMAGAWA Kayoko
Department of Health Chemistry, Faculty of Pharmaceutical Sciences, Hoshi University
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Kawai K
Faculty Of Pharmaceutical Sciences Meijo University
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Fukui T
Byotai-seiri Laboratory
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Fukui T
Department Of Materials Science And Engineering Faculty Of Engineering Kyushu University
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Tamagawa Kayoko
Faculty Of Pharmaceutical Sciences Hoshi University
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