Contribution of Glutathione Peroxidase and Nitric Oxide to Potassium Bromate-Induced Oxidative Stress and Kidney Damage in Mice

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In order to confirm the participation of peroxynitrite in potassium bromate(KBrO_3)-induced oxidative stress and kidney damage in mice, we investigated effects of administration of nitric oxide(NO) synthase inhibitor on them. Cytoplasmic glutathione peroxidase(GPx) activity remarkably decreased within 3 hr after KBrO_3 administration, and then oxidative stress started to occur. However, kidney damage occurred 24 hr after KBrO_3 administration. Pre-administered N^G-monomethyl-L-arginine(L-NMMA), a NO synthase inhibitor, suppressed KBrO_3-induced oxidative stress and kidney damage. However, no effect of L-NMMA was observed on the KBrO_3-induced reduction of cytoplasmic GPx activity. These results suggest that reduction of cytoplasmic GPx activity resulted from the KBrO_3 administration initiates oxidative stress and that NO also participates in the promotion of KBrO_3-induced oxidative stress and kidney damage.
公益社団法人日本薬学会の論文
2001-12-01